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TranscriptomicsThe Sp100 component of ND10/PML bodies is a potent tumor suppressor
The Sp100 component of ND10/PML bodies is a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program. Identifying the functions of proteins, which define specific subnuclear structures and territorie...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-20613 | biostudies-arrayexpress
TranscriptomicsThe Sp100 component of ND10/PML bodies is a potent tumor suppressor
Identifying the functions of proteins, which define specific subnuclear structures and territories, is important for understanding eukaryotic nuclear dynamics. Sp100 is a prototypical protein of ND10/PML bodies and co-localizes with the proto-oncogenic protein PML and Daxx, proteins with critical ro...
ORGANISM(S): Homo sapiens 
2012-12-04 | GSE20613 | GEO
UnknownMediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100.
Not available
S-EPMC1276704 | biostudies-literature
UnknownSp100 provides intrinsic immunity against human papillomavirus infection.
Not available
S-EPMC3892783 | biostudies-literature
GenomicsAn SP110-SP100 axis is a critical regulator of PML body dynamics and mitotic fidelity
Stimulation of the innate immune system by foreign RNA elicits a potent interferon response and can trigger cell death. The mechanisms by which cells balance a robust response with cell-intrinsic lethality are still being uncovered. Employing genome-wide CRISPR-Cas9 genetic screens with triphosphory...
ORGANISM(S): Homo sapiens 
2026-01-25 | GSE304976 | GEO
UnknownSp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle.
Not available
S-EPMC5638619 | biostudies-literature
UnknownMeta-analysis assessment of GP210 and SP100 for the diagnosis of primary biliary cirrhosis.
Not available
S-EPMC4092088 | biostudies-literature
UnknownInterferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins.
Not available
S-EPMC4702707 | biostudies-literature
UnknownCommon properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.
Not available
S-EPMC100253 | biostudies-literature
UnknownSP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis.
Not available
S-EPMC4548144 | biostudies-literature
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