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ProteomicsProteograph™-Based Proteome and Sphingolipidome Analysis for Serological Biomarker Discovery in Long-Duration Space Mission
Introduction: Exposure to microgravity for 180 days leads to significant muscle mass and strength loss, which current countermeasures only partially mitigate. This study aimed to identify novel serological biomarkers to monitor muscle tissue adaptations during and after spaceflight. Serum samples fr...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD069732 | Pride
Glucosylceramide Serological biomarkers Spaceflight serum biomarkers Serum proteomics Sphingolipidomics Proteograph Long-duration space mission Hdl-binding protein (hdlbp) 
UnknownElevated biomarkers of neural injury in older adults following head-down bed rest: links to cardio-postural deconditioning with spaceflight and aging.
Not available
S-EPMC10562592 | biostudies-literature
TranscriptomicsImpact of microgravity on a three-dimensional microphysiologic culture of the human kidney proximal tubule epithelium: cell response to serum and vitamin D
The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular drivers of pathological changes observed in astronauts with the ultimate goals of developing strategies to enable longterm spaceflight and b...
ORGANISM(S): Homo sapiens 
2025-05-12 | GSE268236 | GEO
UnknownLongitudinal metabolomic profiles reveal sex-specific adjustments to long-duration spaceflight and return to Earth.
Not available
S-EPMC11802984 | biostudies-literature
UnknownModeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system.
Not available
S-EPMC11233620 | biostudies-literature
UnknownImpact of microgravity on a three-dimensional microphysiologic culture of the human kidney proximal tubule epithelium: cell response to serum and vitamin D.
Not available
S-EPMC10775397 | biostudies-literature
GenomicsImpact of microgravity on a three-dimensional microphysiologic culture of the human kidney proximal tubule epithelium: cell response to serum and vitamin D
Impact of microgravity on a three-dimensional microphysiologic culture of the human kidney proximal tubule epithelium: cell response to serum and vitamin D
PRJNA1115219 | ENA
UnknownPlasma proteome profiling of healthy subjects undergoing bed rest reveals unloading-dependent changes linked to muscle atrophy.
Not available
S-EPMC9891930 | biostudies-literature
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