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GenomicsTranscriptional Regulation of the GPX1 Gene by TFAP2C and Aberrant CpG Methylation in Human Breast Cancer
The complexity of gene regulation has created obstacles to defining mechanisms that establish the patterns of gene expression characteristic of the different clinical phenotypes of breast cancer. Transcription factor TFAP2C plays a critical role in the regulation of both estrogen receptor-alpha (ERM...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-36351 | biostudies-arrayexpress
ProteomicsThe role of USP7 in TNBC proteomes
The deubiquitinase USP7 plays an important role in tumorigenesis and is a key regulator of the MDM-p53 pathway. Emerging evidence also supports USP7’s p53-independent roles in proliferation and tumorigenesis. Triple negative breast cancers recurrently inactivate p53 and this disease subtype remains ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-21 | PXD059910 | Pride
Tnbc Deubiquitinase Protein degradation Ubiquitin Usp7 
ProteomicsDeep quantitative proteomics of TNBC and SUM149 cell lines treated with USP7 inhibitors
The deubiquitinase USP7 plays an important role in tumorigenesis and is a key regulator of the MDM-p53 pathway. Emerging evidence also supports USP7’s p53-independent roles in proliferation and tumorigenesis. Triple negative breast cancers recurrently inactivate p53 and this disease subtype remains ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-21 | PXD059902 | Pride
Tnbc Deubiquitinase Protein degradation Ubiquitin Usp7 
UnknownEffects of combination lipid therapy in type 2 diabetes mellitus.
Not available
S-EPMC2879499 | biostudies-literature
UnknownEffect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial.
Not available
S-EPMC4123233 | biostudies-literature
UnknownEffects of intensive blood-pressure control in type 2 diabetes mellitus.
Not available
S-EPMC4123215 | biostudies-literature
UnknownEffects of medical therapies on retinopathy progression in type 2 diabetes.
Not available
S-EPMC4026164 | biostudies-literature
UnknownEffects of intensive glucose lowering in type 2 diabetes.
Not available
S-EPMC4551392 | biostudies-literature
UnknownIncorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.
Not available
S-EPMC5013254 | biostudies-literature
UnknownLong-term effects of intensive glucose lowering on cardiovascular outcomes.
Not available
S-EPMC4083508 | biostudies-literature
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