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TranscriptomicsRNAi knockdown of Tip60 and Usp7 in mouse 3T3-L1 adipocytes
Knockdown of Tip60 or Usp7 in differentiated 3T3-L1 adipocytes
ORGANISM(S): Mus musculus 
2013-08-28 | E-TABM-1145 | biostudies-arrayexpress
ProteomicsUSP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and non-catalytic activity
USP7, a ubiquitin-specific peptidase (USP), plays an important role in many cellular processes through its catalytic deubiquitination of various substrates. However, its nuclear function to shape the transcriptional network in mouse embryonic stem cells (mESCs) remains poorly understood. Here, we re...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD039633 | Pride
Pluripotent stem cells  usp7  polycomb  epigenetic regulation 
Transcriptomics3' mRNA-seq of human Ma-Mel-47 (melanoma) and Panc89 (PDAC) cells treated with the USP7 degraders NK266 and NK250, respectively, for 72 h.
3' mRNA-seq was used to study the effects of USP7 degradation by the degraders NK266 and NK250 on gene expression in a human melanoma and PDAC cell line, respectively.
ORGANISM(S): Homo sapiens 
2026-03-27 | E-MTAB-16302 | biostudies-arrayexpress
TranscriptomicsMicroarry from Treg with conditional knockout of Usp7
Microarry from Treg with conditional knockout of Usp7 RNA from three independent samples from FACS sorted CD4+YFP+ Treg of fl-Usp7/Foxp3cre mice, compared to Foxp3cre control (C57BL/6 background).
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-72988 | biostudies-arrayexpress
ProteomicsUSP7, a protein involved in Hao-Fountain syndrome, controls neuronal differentiation via BCOR-ncPRC1.1
Pathogenic variants in the ubiquitin-specific protease 7 (USP7) gene cause a neurodevelopmental disorder called Hao-Fountain syndrome. However, which of its pleiotropic substrates are relevant for neurodevelopment is undetermined. Here, we present a combination of quantitative proteomics, transcript...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD051616 | Pride
Usp7 Prm Dia-ms Label free quantitative proteomics Neuronal differentiation Bcor Hao-fountain syndrome 
GenomicsUSP7 substrates identified by proteomics analysis reveal the specificity of USP7
USP7 substrates identified by proteomics analysis reveal the specificity of USP7
PRJNA752331 | ENA
TranscriptomicsYG001: A Usp7-Tip60 pathway regulates early adipogenesis
USP7, a dominant DUB activity in 3T3-L1 adipocytes and in mouse adipose tissue, increases Tip60 protein levels, and deubiquitinates Tip60 both in intact cells and in vitro. Treatment with a pan deubiquitinase (DUB) inhibitor, or knockdown of USP7, decreases adipogenesis. Transcriptome analysis revea...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-28587 | biostudies-arrayexpress
ProteomicsProteomic analysis of USP7 conditional KO mouse cerebral cortices
A proteomic comparison of the cerebral cortices of USP7 conditional KO mice versus controls using 10-plex TMT mass spec
ORGANISM(S): Mus musculus (Mouse) 
2025-02-24 | PXD043848 | Pride
Usp7 Cerebral cortex 
ProteomicsProteomic analysis of primary cortical neurons in response to acute USP7 loss
A proteomic characterization of primary mouse cortical neurons in response to acute USP7 depletion using 16-plex TMT mass spec
ORGANISM(S): Mus musculus (Mouse) 
2025-02-24 | PXD043849 | Pride
Usp7 Cortical neuron 
ProteomicsThe role of USP7 in TNBC proteomes
The deubiquitinase USP7 plays an important role in tumorigenesis and is a key regulator of the MDM-p53 pathway. Emerging evidence also supports USP7’s p53-independent roles in proliferation and tumorigenesis. Triple negative breast cancers recurrently inactivate p53 and this disease subtype remains ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-21 | PXD059910 | Pride
Tnbc Deubiquitinase Protein degradation Ubiquitin Usp7 
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