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TranscriptomicsChromatin immunoprecipitation of transcription factor Dpf3 in mouse myoblast cells (C2C12) to identify genome wide binding sites
The aim of the experiment was to identify genome wide binding sites for the transcription factor Dpf3 by using Chromatin Immunoprecipitation followed by microarray analysis (ChIP-chip) in C2C12 cells.
ORGANISM(S): Mus musculus 
2008-08-01 | E-TABM-362 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish embryos with dpf3 knocked down for morpholino
An experiment was performed to analyze the effect of knockdown of dpf3 during zebrafish embryogenesis.Morpholino against dpf3 and control morpholino were injected into eggs and eggs were kept under standard conditions for 72 hours. Embroys were harvested, total RNA was extracted and used for microar...
ORGANISM(S): Danio rerio 
2008-08-01 | E-TABM-354 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation to identify binding sites for Gata4, Mef2a, Nkx2.5, Srf, p300, Pol_II, H3ac, H3K4me1 in mouse cardiomyocyte cell line, HL1
The aim of the experiment was to identify genome wide binding sites for Gata4, Mef2a, Nkx2.5, Srf, p300, Pol_II, H3ac, H3K4me1 by using Chromatin Immunoprecipitation followed by microarray analysis (ChIP-chip) in HL1 cells.
ORGANISM(S): Mus musculus 
2011-01-05 | E-TABM-378 | biostudies-arrayexpress
GenomicsIdentification of transcription factor Srf binding sites and histone 3 actetylated regions in mouse cardiomyocytes
We investigated the cardiac transcription network driven by the DNA-binding key factor Srf in combination with epigenetic marks of histone 3 acetylation (H3ac). Srf has been shown to play a key role in cardiac cell growth and muscle gene regulation. However, we still have limited understanding of th...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-19065 | biostudies-arrayexpress
TranscriptomicsSmall RNA sequencing in mouse cardiomyocytes after siRNA mediated knockdown of Srf
We performed two independent siRNA mediated knockdowns of Srf (Srf si1 & Srf si2) and an unspecific siRNA (siNon) in mouse cardiomyocytes HL-1 cells. Small RNAs were sequenced by Illumina/Solexa next-generation (single-end) sequencing technology. The sequence reads were mapped to the mouse reference...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-19066 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiling in patients with Tetralogy of Fallot and healthy unaffected individuals
Right ventricular mRNA profiles from 22 patients with Tetralogy of Fallot (TOF) and mRNA-seq profiles from the left and right ventricle (LV and RV, respectively) of 4 healthy unaffected individuals (NH) were generated. The total RNA was isolated from the 30 human heart samples using TRIzol. mRNAs we...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-36761 | biostudies-arrayexpress
GenomicsComparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases
The most common congenital heart disease (CHD) is the ventricular septal defect (VSD), which is also a subfeature of Tetralogy of Fallot (TOF) representing the most common form of cyanotic CHD. The underlying causes for the majority of CHDs are still unclear and most probably consist of combinations...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-62629 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse HL1, C2C12 differentiated and C2C12 undifferentiated cells with four histone modifications
The combinatorial effects of four histone modifications in transcription and differentiation. Two replicates per histone modification and cell type.
ORGANISM(S): Mus musculus 
2007-10-17 | E-TABM-182 | biostudies-arrayexpress
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