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State Key Laboratory of Reproductive Medicine and Offspring Health， Nanjing Medical University, Nanjing, China. (1)
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Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation

The gene Sly is present in multiple copies on the mouse Y chromosome and encodes a protein that is required for the epigenetic regulation of postmeiotic sex chromosome expression. The X chromosome carries two multicopy genes related to Sly: Slx and Slxl1. Here we investigate the role of Slx/Slxl1 us...

ORGANISM(S): Mus musculus

2011-05-11 | E-GEOD-29197 | biostudies-arrayexpress

Testis-expressed cluster of microRNAs 959-964 controls spermatid differentiation in Drosophila melanogaster

MicroRNAs are a wide class of ~22 nt non-coding RNAs of metazoans capable of inhibiting target mRNAs translation by binding to partially complementary sites in their 3â€™UTRs. Due to their regulatory potential, miRNAs are implicated in functioning of a broad range of biological pathways and processe...

ORGANISM(S): Drosophila melanogaster

2015-10-29 | E-MTAB-3214 | biostudies-arrayexpress

Transcription profiling of mouse germline during spermatogenesis reveals X and Y occupy a novel compartment in the post-meiotic spermatid and adopt a non-Rabl configuration

In mammals, the X and Y chromosomes are subject to meiotic sex chromosome inactivation (MSCI) during prophase I in the male germline, but their status thereafter is currently unclear. An abundance of X-linked spermatogenesis genes has spawned the view that the X must be active [1-8]. On the other ha...

ORGANISM(S): Mus musculus

2007-12-07 | E-GEOD-4193 | biostudies-arrayexpress

Expression data from 30do mouse spermatid [Affymetrix]

Chromatin performs numerous functions during cellular differentiation, and therefore it must be capable of adopting a multitude of different structures. How these various structures are established is poorly understood, but we propose that specific histone H2A variants will have a key role in remode...

ORGANISM(S): Mus musculus

2012-01-20 | E-GEOD-29781 | biostudies-arrayexpress

Tsga8 is required for spermatid morphogenesis and male fertility in mice

PRJNA619065 | ENA

Distinct roles of two myosins in C. elegans spermatid differentiation.

Not available

S-EPMC6485759 | biostudies-literature

Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis.

Not available

S-EPMC8217706 | biostudies-literature

A testis-specific long non-coding RNA, 1700052I22Rik, regulates spermatid chromatin condensation in mice

PRJNA1183555 | ENA