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MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
ProteomicsA bioenergetic shift is required for spermatogonial differentiation
A bioenergetic balance between glycolysis and mitochondrial respiration is particularly important for stem cell fate specification. It however remains to be determined whether undifferentiated spermatogonia switch their preference of bioenergy production during differentiation. In this study, we fou...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019136 | Pride
Spermatogonial differentiation Oxphos Glycolysis 
TranscriptomicsDNMT3L promotes quiescence in postnatal spermatogonial progenitor cells
We analyzed transcriptome profiles of postnatal germ cells and demonstrated that DNMT3L is important for spermatogonial stem/progenitor cell development Examination of wild-type and Dnmt3l knockout smaples in postnatal male germ cells
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-54411 | biostudies-arrayexpress
TranscriptomicsExpression data from aged spermatogonial stem cells
In vitro and in vivo aging of mouse spermatogonial stem cells alters stem cell function based on quantitative spermatogonial stem cell transplantation analyses. We used microarrays to identify differential gene expression in vitro and in vivo aged spermatogonial stem cells to identify potential caus...
ORGANISM(S): Mus musculus 
2011-02-04 | E-GEOD-27043 | biostudies-arrayexpress
TranscriptomicsExpression data from testis of day-7 Sohlh1 knock-out mice
Sohlh1 and Sohlh2 encode a germ cell-specific basic helix-loop-helix transcriptional regulator critical in spermatogonial differentiation. Seven-day-old Sohlh1 or Sohlh2 knockout and wild-type testes were arrayed on the Affy 430 2.0 platform. The following mice were analyzed at postnatal day 7: wild...
ORGANISM(S): Mus musculus 
2010-05-07 | E-GEOD-21525 | biostudies-arrayexpress
GenomicsRetinoic acid dependent spermatogonial differentiation in mice
Retinoic acid dependent spermatogonial differentiation in mice
PRJNA882096 | ENA
TranscriptomicsSequencing of microRNA in spermatogonial stem cell enriched cell populations.
MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue systems where their functions include the regulation of self-renewal, cellular differentiation, proliferation, and apoptosis. However, the functional importance of individual miRs in controlling spermatogoni...
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-29613 | biostudies-arrayexpress
GenomicsPPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation
PPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation
PRJNA1165730 | ENA
ProteomicsComparative nuclear proteomic analysis between undifferentiated and differentiation-initiated mouse spermatogonial stem cell cultures
Mouse spermatogonial stem cells (SSCs) continuously self-renew on the feeder layers in serum-free culture medium supplemented with glial cell line-derived neurotrophic factor and fibroblast growth factor 2. To identify novel nuclear proteins involved in SSC maintenance, comparative proteomic profili...
ORGANISM(S): Mus Musculus (mouse) 
2024-09-27 | PXD045716 | JPOST Repository
GenomicsDIS3L2 is an essential regulator of spermatogonial differentiation in mice
DIS3L2 is an essential regulator of spermatogonial differentiation in mice
PRJNA671842 | ENA
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