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TranscriptomicsDNMT3L promotes quiescence in postnatal spermatogonial progenitor cells
We analyzed transcriptome profiles of postnatal germ cells and demonstrated that DNMT3L is important for spermatogonial stem/progenitor cell development Examination of wild-type and Dnmt3l knockout smaples in postnatal male germ cells
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-54411 | biostudies-arrayexpress
TranscriptomicsSequencing of microRNA in spermatogonial stem cell enriched cell populations.
MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue systems where their functions include the regulation of self-renewal, cellular differentiation, proliferation, and apoptosis. However, the functional importance of individual miRs in controlling spermatogoni...
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-29613 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spermatogonial stem cells established from 6 day old male mice to identify GDNF regulated genes by comparing cells in the presence, absence and timed replacement of GDNF
GDNF-regulated gene expression was studied in cultures of actively self-renewing spermatogonial stem cells established from 6 day old male mice. GDNF is the essential growth factor regulating mouse spermatogonial stem cell self-renewal. Using a serum-free chemically defined culture system that suppo...
ORGANISM(S): Mus musculus 
2007-11-24 | E-GEOD-4799 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of laminin binding and laminin non-binding germ cells to define the spermatogonial stem cells.
Comparison of laminin binding and laminin non-binding germ cells.
ORGANISM(S): Mus musculus 
2007-12-19 | E-GEOD-829 | biostudies-arrayexpress
TranscriptomicsExpression data of CD9 positive germ cells from young and aged Sprague Dawley germ cell specific GFP rats
Male fertility and testis function changes with age and so it was sought to determine if these changes are accompanied by changes in gene expression in the spermatogonial cells at the foundation of spermatogenesis A full genome microarray was used to determine if distinct pathways of genes were alte...
ORGANISM(S): Rattus norvegicus 
2013-12-05 | E-GEOD-50143 | biostudies-arrayexpress
TranscriptomicsExpression data from aged spermatogonial stem cells
In vitro and in vivo aging of mouse spermatogonial stem cells alters stem cell function based on quantitative spermatogonial stem cell transplantation analyses. We used microarrays to identify differential gene expression in vitro and in vivo aged spermatogonial stem cells to identify potential caus...
ORGANISM(S): Mus musculus 
2011-02-04 | E-GEOD-27043 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of mouse germ cells
Spermatogenesis is a recurring differentiation process that results in the production of male gametes within the testes. During this process, spermatogonial stem cells differentiate to form spermatocytes, which undergo two rounds of meiotic division to form haploid spermatids. Throughout spermiogene...
ORGANISM(S): Mus musculus 
2019-01-25 | E-MTAB-6946 | biostudies-arrayexpress
GenomicsRepression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development
Polycomb-repressive complex 2 (PRC2) catalyzes the methylation of histone H3 Lys27 (H3K27) and functions as a critical epigenetic regulator of both stem cell pluripotency and somatic differentiation, but its role in male germ cell development is unknown. Using conditional mutagenesis to remove the c...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-61902 | biostudies-arrayexpress
TranscriptomicsWhole transcription data for mouse spermatogonial cells
Spermatogenesis is a multi-step yet tightly regulated developmental process to produce male gemetes for reproduction. In mouse spermatogenesis, a sub-group of type A spermatogonia (Spga) known as spermatogonial stem cells (SSCs) maintain their population by self-renewal, and differentiate through mi...
ORGANISM(S): Mus musculus 
2014-02-27 | E-GEOD-55381 | biostudies-arrayexpress
ProteomicsA bioenergetic shift is required for spermatogonial differentiation
A bioenergetic balance between glycolysis and mitochondrial respiration is particularly important for stem cell fate specification. It however remains to be determined whether undifferentiated spermatogonia switch their preference of bioenergy production during differentiation. In this study, we fou...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019136 | Pride
Spermatogonial differentiation Oxphos Glycolysis 
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