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MetabolomicsSphingolipid-dependent Dscam sorting regulates axon segregation
Neurons are highly polarized cells with distinct protein compositions in axonal and dendritic compartments. Cellular mechanisms controlling polarized protein sorting have been described for mature nervous system but little is known about the segregation in newly differentiated neurons. In a forward ...
2019-03-29 | MTBLS825 | MetaboLights
MetabolomicsUntargeted metabolomics identifies a plasma sphingolipid-related signature associated with lifestyle intervention in prepubertal children with obesity

OBJECTIVE: Childhood obesity is a strong risk factor for adult obesity and metabolic diseases, including type 2 diabetes and cardiovascular disease. Early lifestyle intervention in children with obesity reduces future disease risk. The objective of this study is to identify metab...

2018-02-09 | MTBLS423 | MetaboLights
MetabolomicsInfluenza A virus H1N1 infection alters sphingolipid metabolism in A549 cells
This study investigates metabolic alterations in A549 cells infected with influenza A virus H1N1 (WSN strain). Untargeted metabolomics analysis was performed using liquid chromatography coupled with mass spectrometry (LC-MS) in both positive and negative ionization modes. The study aims to character...
2026-07-29 | MTBLS15182 | MetaboLights
MetabolomicsSeipin Governs Caveolin-1 Trafficking Through Modulating Sphingolipid-Glycerolipid Balance

Dysregulation of Caveolin-1 (CAV1), a key component of caveolae, leads to pleiotropic disorders; yet, the mechanisms controlling its trafficking remain unclear. Here, we show that the lipid droplet (LD) biogenesis factor seipin controls CAV1 localization. Seipin deficiency in mice and HeLa cells ...

2025-07-22 | MTBLS12759 | MetaboLights
MetabolomicsMetabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide
Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs. The anti-trypanosomal compound, 3-(oxazolo[4,5-b]pyridine-2-yl)anilide (OXPA), was init...
2017-10-09 | MTBLS360 | MetaboLights
MetabolomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes liquid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chro...
2026-04-01 | MTBLS14166 | MetaboLights
MetabolomicsEMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress
The long-term maintenance of hematopoietic stem cells (HSCs) relies on the regulation of endoplasmic reticulum (ER) stress at a low level, but the underlying mechanism remains poorly understood. Here, we demonstrate that suppression of ER stress improves the functions of HSCs and protects HSCs again...
2025-06-04 | MTBLS12489 | MetaboLights
MetabolomicsEMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress
The long-term maintenance of hematopoietic stem cells (HSCs) relies on the regulation of endoplasmic reticulum (ER) stress at a low level, but the underlying mechanism remains poorly understood. Here, we demonstrate that suppression of ER stress improves the functions of HSCs and protects HSCs again...
2025-06-04 | MTBLS12491 | MetaboLights
ProteomicsAn ERAD independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
Nearly one-third of nascent proteins are initially targeted to the endoplasmic reticulum (ER) where they are correctly folded and assembled before being delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated-degradation (ERAD) remove...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
MSV000090333 | MassIVE
MetabolomicsHuman TM Sphingolipid Analysis (part II)
Not available
ORGANISM(S): Homo sapiens 
ST000613 | MetabolomicsWorkbench
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