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TranscriptomicsThe role of SphK1 in hTNFα induced inflammation
The study analyzes analyzes gene expression changes in the ankle joint in mouse TNFa overexpression models with or without sphingosine kinase 1 activity. SphK1 is a sphingolipid enzyme that converts sphingosine to bioactive sphingosine-1-phosphate (S1P). Recent data suggest a potential relationship...
ORGANISM(S): Mus musculus 
2011-01-15 | E-GEOD-20152 | biostudies-arrayexpress
TranscriptomicsThe role of SphK1 in hTNFα induced inflammation
The study analyzes analyzes gene expression changes in the ankle joint in mouse TNFa overexpression models with or without sphingosine kinase 1 activity. SphK1 is a sphingolipid enzyme that converts sphingosine to bioactive sphingosine-1-phosphate (S1P). Recent data suggest a potential relationship ...
ORGANISM(S): Mus musculus 
2011-01-15 | GSE20152 | GEO
GenomicsLoss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma
Loss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma
PRJNA1173172 | ENA
GenomicsEffects of Sphk1 deletion in smooth muscle cells on murine arterial transcriptome in hypertension
Effects of Sphk1 deletion in smooth muscle cells on murine arterial transcriptome in hypertension
PRJNA1304912 | ENA
GenomicsLoss of SPHK1 recruits pro-tumorigenic macrophagese to drive lung adenocarcinoma
Loss of SPHK1 recruits pro-tumorigenic macrophagese to drive lung adenocarcinoma
PRJNA1159187 | ENA
GenomicsMast cell CRFR1 contributes to pancreatic cancer pain via MAPK/SPHK1 signaling
Mast cell CRFR1 contributes to pancreatic cancer pain via MAPK/SPHK1 signaling
PRJNA1368828 | ENA
UnknownTherapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases.
Not available
S-EPMC8560647 | biostudies-literature
TranscriptomicsEffects of Sphk1 deletion in smooth muscle cells on murine arterial transcriptome in hypertension
The function of the cardiovascular system is regulated by sphingosine-1-phosphate (S1P) signalling. Vascular sphingosine kinase 1 (Sphk1), an S1P-producing enzyme, is upregulated in hypertension (HTN), and mice lacking Sphk1 globally exhibit alleviated angiotensin II (AngII)-induced HTN. Identifying...
ORGANISM(S): Mus musculus 
2026-04-07 | GSE305242 | GEO
TranscriptomicsLoss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma
Inflammation is a widely recognized key contributor to KRAS-driven lung adenocarcinoma. Tumor associated macrophages are integral part of the tumor microenvironment, creating a supportive niche to sustain tumorigenesis. In the present study, we unravel a dichotomic role of sphingosine kinase 1 (SPHK...
ORGANISM(S): Mus musculus 
2025-10-06 | GSE279515 | GEO
GenomicsGene and microRNA expression changes induced by overexpression of SphK1 in papillary thyroid cancer cells [miRNA-seq]
The oncogenic roles of Sphingosine kinase 1 (SphK1) in various cancers, including thyroid cancer, have been well demonstrated. However, miRNAs associated with the oncogenic roles of SphK1 remains largely unknown. The goal of this study is to detect the global gene and microRNA (miRNA) expression in ...
ORGANISM(S): Homo sapiens 
2016-09-24 | GSE87310 | GEO
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