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ProteomicsDiscovery of potential candidate proteins reprogramming spinal cord derived astrocytes into neurons by proteomic analysis
Spinal cord injury (SCI) is a common but devastating trauma of the central nerve system. In this study, we reprogrammed cultured spinal-cord reactive astrocytes into neurons by Neurod1 expression. The mechanism of programmed conversion from astrocytes to neurons has not been clarified yet. Thus, we ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD016097 | Pride
Spinal cord injury Astrocytes Neurons Label-free proteomic analysis Reprogramming 
TranscriptomicsLysosomal and phagocytic activity is increased in astrocytes during the progression of amyotrophic lateral sclerosis
The aim of the present study is to combine LCM and microarray analysis to study how astrocytes in the spinal cord of transgenic SOD1 G93A mice and their non-transgenic (NTg) littermates respond to stimuli determined by the presence of the human mutant protein throughout the evolution of the disease ...
ORGANISM(S): Mus musculus 
2015-11-02 | E-GEOD-69166 | biostudies-arrayexpress
TranscriptomicsTenascin-C modifies expression levels and territories of key patterning genes during spinal cord astrocyte specification [mus musculus]
We demonstrate for the first time that the extracellular matrix glycoprotein Tenascin-C regulates the expression of key patterning genes during late embryonic spinal cord development, leading to a timely maturation of gliogenic neural precursor cells. We first show that Tenascin-C is expressed by gl...
ORGANISM(S): Mus musculus 
2011-10-19 | E-GEOD-33091 | biostudies-arrayexpress
TranscriptomicstrkB.T1 WT versus trkB.T1 KO expression data following spinal cord injury (SCI)
We profiled spinal cord tissue at the site of a moderate contusion injury at the level of the thoracic spinal cord We examined several timepoints following injury, including sham and days 1,3 and 7 following injury and compared differential expression of genes within a genotype and across genotypes ...
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-47681 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat spinal cord with experimental autoimmune encephalomyelitis at 3 disease points, acute, relapsing and recovering vs. controls
The intention of the study was to examine the spinal cord gene expression at three different EAE disease points and to compare them with three nonimmunised, healthy rats. We immunised female DA rats with recombinant MOG-protein and sacrificed them during the acute phase of EAE defined as the first E...
ORGANISM(S): Rattus norvegicus 
2007-05-15 | E-MEXP-1025 | biostudies-arrayexpress
TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
TranscriptomicsAstrocyte-encoded positional cues maintain sensorimotor circuit integrity
Astrocytes, the most abundant cells in the central nervous system, promote synapse formation and help refine neural connectivity. Although they are allocated to spatially distinct regional domains during development, it is unknown whether region-restricted astrocytes are functionally heterogeneous. ...
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-55054 | biostudies-arrayexpress
UnknownMorphological regulation of wound repair astrocytes by leucine zipper-bearing kinase-AKT signaling after spinal cord injury.
Not available
S-EPMC12404237 | biostudies-literature
TranscriptomicsGene expression in astrocytes upon sustained GSK-3 inhibition by small molecule
In order to identify molecular targets that mediates the stimulation of astrocyte's migration upon sustained specific inhibition of GSK-3, we have employed whole genome microarray expression profiling. Murine cortical-striatal astrocytes grown in primary culture were treated in vitro for 48 h with e...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-25770 | biostudies-arrayexpress
ProteomicsPerturbations of the proteome in primary astrocytes from the hSOD1(G93A) ALS mouse model
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease whose pathophysiology is largely unknown. Despite motor neuron death is recognized as the key event in ALS, astrocytes dysfunctionalities and neuroinflammation were demonstrated to accompany and probably even drive motor ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026576 | Pride
Spinal cord astrocytes Amyotrophic lateral sclerosis Mouse Lc-hrms/ms 
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