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TranscriptomicsGene Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)
Myelin Basic Protein (MBP) induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat, produces an an acute weakness, or paralysis of the tail and hind limb ataxia ,weakness or paralysis associated with increased permiability of the blood brain barrier, inflammation and demyelination i...
ORGANISM(S): Rattus norvegicus 
2013-04-03 | E-GEOD-39119 | biostudies-arrayexpress
MetabolomicsEVOLUTION OF THE LIPIDOME UNCOVERS EARLY CHANGES IN ADRENOLEUKODYSTROPHY HUMAN CORTICAL AND SPINAL ORGANOIDS

Lipids are critical for the structure, signaling, and metabolism of the central nervous system (CNS), yet their roles during human brain development remain underexplored due to limited tissue availability. X-linked adrenoleukodystrophy (ALD), a peroxisomal disorder caused by ABCD1 mutat...

2025-11-17 | MTBLS12973 | MetaboLights
TranscriptomicsDifferential Response Following Spinal Cord Injury in EphA4 Knockout
Mice lacking the developmental axon guidance molecule EphA4 have previously been shown to exhibit extensive axonal regeneration and functional recovery following spinal cord injury. To assess mechanisms by which EphA4 may modify the response to neural injury, a microarray was performed on spinal co...
ORGANISM(S): Mus musculus 
2012-05-23 | E-GEOD-34430 | biostudies-arrayexpress
TranscriptomicsDanio spinal cord injury
Adult zebrafish have the ability to recover from spinal cord injury and exhibit re-growth of descending axons from the brainstem to the spinal cord. We performed gene expression analysis using microarray to find damage-induced genes after spinal cord injury, which shows that Sox11b mRNA is up-regula...
ORGANISM(S): Danio rerio 
2010-10-19 | E-GEOD-20460 | biostudies-arrayexpress
TranscriptomicsExpression data from adult wistar female rat 5mm spinal cord tissue
We used microarray gene expression analyses to unveil the mechanisms underlying NT-3-chitosan-induced spinal cord regeneration. Complete transaction of thoracic spinal cord at T7/8 was performed, with a 5 mm segment of the spinal cord being removed. The emptied space where either refilled with a 5mm...
ORGANISM(S): Rattus norvegicus 
2015-11-02 | E-GEOD-69334 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in the spinal cord below the lesion level and influence of treadmill locomotor training
Traumatic spinal cord injury (SCI) often leads to loss of locomotor function. Neuroplasticity of spinal circuitry underlies some functional recovery and therefore represents a therapeutic target to improve locomotor function following SCI. However, the cellular and molecular mechanisms mediating neu...
ORGANISM(S): Rattus norvegicus 
2013-11-27 | E-GEOD-52763 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of expression of cell death-associated genes in rat spinal cord cells exposed to cyclic tensile stresses in vitro
The application of mechanical insults to the spinal cord results in profound cellular and molecular changes, including the induction of neuronal cell death and altered gene expression profiles. We demonstrated that spinal cord cells undergo cell death in response to cyclic tensile stresses, which we...
ORGANISM(S): Rattus norvegicus 
2010-07-08 | E-GEOD-22791 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and Abcd1 -/- spinal cord over time to study X-Adrenoleukodystrophy (X-Ald) disease progression
X-Adrenoleukodystrophy (X-Ald) disease progression was studied by comparing expression patterns of Abcd1 -/- mouse spinal cords from 3.5, 12 and 22 months of age compared to healthy littermates spinal cords at the same time points.
ORGANISM(S): Mus musculus 
2011-01-12 | E-MTAB-79 | biostudies-arrayexpress
TranscriptomicsRNA-Seq characterization of spinal cord injury transcriptome in acute/subacute phases: a resource for understanding the pathology at the systems level
Purpose: Spinal cord injury (SCI) is a devastating neurological disease without effective treatment. To generate a comprehensive view of the mechanisms involved in SCI pathology, we applied RNA-sequencing (RNA-seq) technology to characterize the temporal changes in global gene expression after contu...
ORGANISM(S): Mus musculus 
2013-08-22 | E-GEOD-45376 | biostudies-arrayexpress
TranscriptomicsExpression data from adult rat tail MNs after spinal cord transection
Spinal cord injury leads to impaired motor and sensory functions. After spinal cord injury there is a an initial phase of hypo-reflexia followed by a developing hyper-reflexia, often termed spasticity. Previous studies have suggested a relationship between the reappearence of plateau potentials in m...
ORGANISM(S): Rattus norvegicus 
2009-10-31 | E-GEOD-16710 | biostudies-arrayexpress
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