Sort   by:  
 Page size 
ProteomicsComparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice define disease-relevant pathways
Netherton syndrome (NS) is a rare skin disease caused by loss-of-function mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) gene. Disease severity and the lack of efficacious treatments call for a better understanding of NS mechanisms. Here we describe a viable, Spink5 conditional kn...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-02-02 | MSV000091184 | MassIVE
GenomicsTranscriptome profiling of lesional skin from Spink5 conditional knock-out mice
Transcriptome profiling of lesional skin from Spink5 conditional knock-out mice
PRJNA930447 | ENA
GenomicsTranscriptome profiling of lymph nodes from Spink5 conditional knock-out mice.
Transcriptome profiling of lymph nodes from Spink5 conditional knock-out mice.
PRJNA930882 | ENA
GenomicsTranscriptome profiling of lesional skin from neonate Spink5 constitutive knock-out mice
Transcriptome profiling of lesional skin from neonate Spink5 constitutive knock-out mice
PRJNA932026 | ENA
TranscriptomicsTranscriptome profiling of lesional skin from Spink5 conditional knock-out mice
We generated a viable mouse model of Netherton syndrome by conditional ablation of Spink5 gene in the epidermis. To characterize this model at the molecular level, we induced Spink5 deletion in young adult mice and collected lesional skin samples for transcriptome analyses.
ORGANISM(S): Mus musculus 
2024-02-05 | GSE224280 | GEO
TranscriptomicsTranscriptome profiling of lymph nodes from Spink5 conditional knock-out mice.
We generated a viable mouse model of Netherton syndrome by conditional ablation of Spink5 gene in the epidermis. To study the systemic inflammation phenotype of this mouse model at the molecular level, we induced Spink5 deletion in the skin of young adult mice and collected inguinal lymph nodes for ...
ORGANISM(S): Mus musculus 
2024-02-05 | GSE224409 | GEO
GenomicsSTAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes
STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes
PRJNA699446 | ENA
UnknownA novel SPINK5 donor splice site variant in a child with Netherton syndrome.
Not available
S-EPMC8104165 | biostudies-literature
UnknownA novel tumor suppressor SPINK5 targets Wnt/β-catenin signaling pathway in esophageal cancer.
Not available
S-EPMC6537088 | biostudies-literature
UnknownMetformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis.
Not available
S-EPMC9199130 | biostudies-literature
Sort   by:  
 Page size