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Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-09-22 | MTBLS15760 | MetaboLights
Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-09-01 | MTBLS15516 | MetaboLights
Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-08-30 | MTBLS15501 | MetaboLights
Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-09-14 | MTBLS15663 | MetaboLights
Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-09-14 | MTBLS15643 | MetaboLights
TranscriptomicsTranscription profiling of human fibroblasts infected with adenoviruses encoding for STREBP1c
We compared the gene expression profiles of AG01518 human fibroblasts infected with adenoviruses encoding for SREBP1c. Cells infected with mock virus are used as a reference.
ORGANISM(S): Homo sapiens 
2007-04-26 | E-TABM-215 | biostudies-arrayexpress
TranscriptomicsMicroarrays analysis of SREBP-1a and SREBP-1c target genes identify new regulatory pathways.
In this study we have identified the target genes of SREBP1a and SREBP1c in primary cultures of human skeletal muscle cells using adenoviral vectors expressing the mature nuclear form of human SREBP1a or SREBP1c combined with oligonucleotide microarrays. Keywords: comparison of human myotubes infec...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10918 | biostudies-arrayexpress
GenomicsMus musculus strain:C57Bl6/J mice | breed:Srebp1c-KO and Wild-Type
Mus musculus strain:C57Bl6/J mice | breed:Srebp1c-KO and Wild-Type Transcriptome or Gene expression
PRJNA1167636 | ENA
TranscriptomicsAnalysis of transcriptome profiling in liver tissues of wild-type and SREBP1c knockout mice using RNA-seq
Sterol regulatory element-binding protein 1c (SREBP1c) plays important roles in lipid metabolism and cell proliferation. To identify novel target genes of SREBP1c, particularly, in cell cycle regulation, we analyzed transcriptome profiling (RNA-seq) in liver tissue of wild-type and SREBP1c knockout ...
ORGANISM(S): Mus musculus 
2017-09-11 | GSE100827 | GEO
UnknownC/EBP transcription factors regulate SREBP1c gene expression during adipogenesis.
Not available
S-EPMC2913385 | biostudies-literature
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