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UnknownCortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.

Background

Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder. Notwithstanding the extensive studies using rodent and other pre-clinical models of FXS, which have provided detailed mechanistic insigh...
S-EPMC7304215 | biostudies-literature
UnknownSTK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.
KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) comutations define distinct subgroups of KRAS-mutant LUAC. Here, we examine the efficacy of PD-1 inhibitors in these subgroups. Objective respo...
S-EPMC6030433 | biostudies-literature
UnknownDropwise condensation of low surface tension fluids on omniphobic surfaces.
Compared to the significant body of work devoted to surface engineering for promoting dropwise condensation heat transfer of steam, much less attention has been dedicated to fluids with lower interfacial tension. A vast array of low-surface tension fluids such as hydrocarbons, cryogens, and fluorina...
S-EPMC3942741 | biostudies-literature
UnknownDexamethasone in Hospitalized Patients with Covid-19.

Background

Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death.

Methods

In this controlled, open-label trial comparing a range of poss...
S-EPMC7383595 | biostudies-literature
UnknownHigh prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.

Background

Patients with congenital heart disease (CHD) and heterotaxy show high postsurgical morbidity/mortality, with some developing respiratory complications. Although this finding is often attributed to the CHD, airway clearance and left-right patterning both require motile cilia functi...
S-EPMC3770728 | biostudies-literature
ProteomicsProteomic analysis of human anterior pituitary gland
The regulation of pituitary function via the hypothalamus and via intra-pituitary connections represents a complex system. Though hormones secreted from the pituitary glands have been well studied, overall information of proteins expressed in the pituitary glands is very limited. Protein expression ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-02 | PXD005819 | Pride
Adenohypophysis Anterior pituitary gland Proteomics 
UnknownUse of p53 immunohistochemistry can improve diagnostic agreement for differentiated vulvar intraepithelial neoplasia (dVIN): an international reproducibility study.

Aims

Differentiated or HPV-independent vulvar intraepithelial neoplasia (dVIN) can progress rapidly to invasive cancer and accurate pathological diagnosis is essential to facilitate appropriate interventions. Histological similarities of dVIN with non-neoplastic lesions, however, often make ...
S-EPMC12703432 | biostudies-literature
UnknownApproach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort.
Characterization of toxicity associated with cancer and its treatment is essential to quantify risk, inform optimization of therapeutic approaches for newly diagnosed patients, and guide health surveillance recommendations for long-term survivors. The NCI Common Terminology Criteria for Adverse Even...
S-EPMC5413397 | biostudies-literature
UnknownBelzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.

Background

Patients with von Hippel-Lindau (VHL) disease have a high incidence of renal cell carcinoma owing to VHL gene inactivation and constitutive activation of the transcription factor hypoxia-inducible factor 2α (HIF-2α).

Methods

In this phase 2, open-label, single-group ...
S-EPMC9275515 | biostudies-literature
UnknownProteomic Analysis of the Human Anterior Pituitary Gland.
The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of ...
S-EPMC6425986 | biostudies-literature
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