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ProteomicsSplicing Factor SRSF1 Deficiency in the Liver Triggers NASH-like Pathology via R-Loop Induced DNA Damage and Cell Death
Regulation of RNA processing contributes profoundly to tissue development and physiology. The serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte function and survival. Although SRSF1 is mainly known for its many roles in mRNA metabolism, it is also crucial for maintaining gen...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD027035 | Pride
Srsf1 Liver Hepatocyte Splicing 
ProteomicsTranslational activity of the splicing factor SRSF1 is required for development and cilia function
The SR protein family of splicing factors regulate constitutive and alternative pre-mRNA splicing. A subset of them, including SRSF1, shuttles continuously between the nucleus and cytoplasm affecting post-splicing processes. We have previously identified a role for SRSF1 in promoting the translation...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-06 | PXD019859 | Pride
Sr proteins/ srsf1/ mrna translation/ alternative splicing/ cilia 
GenomicsSRSF1 HITS-CLIP
SRSF1 HITS-CLIP
PRJNA541847 | ENA
TranscriptomicsThe RNAseq of 79 small cell lung cancer (sclc) and 7 normal control
Even though small cell lung cancer (SCLC) has entered the age of broad genomic analysis, platinum-based chemotherapy remains the standard care for SCLC. Topotecan is the only approved agent for recurrent or progressive SCLC (1). In the absence of well-defined genomic biomarkers, clinical efficacy s...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-60052 | biostudies-arrayexpress
TranscriptomicsIdentification of alternative splicing events regulated by the splicing factor SRSF1 using data from exon-junction microarray technologies
Analysis to identify genome-wide differential alternative splicing events in A549 cells in which the levels of the gene SRSF1 were down-regulated with a specific siRNA 9 samples from three independent experiments using A549 cells transfected with lipofectamine alone, scramble siRNA or SRSF1 siRNA
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-53410 | biostudies-arrayexpress
GenomicsNext Generation Sequencing Analysis of SRSF1 flox/flox and SRSF1-KO pancreatic islet Transcriptome
Next Generation Sequencing Analysis of SRSF1 flox/flox and SRSF1-KO pancreatic islet Transcriptome
PRJNA725671 | ENA
TranscriptomicsPAR-CLIP analysis of YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 and SRSF10 in human HeLa cells
Label the cells overexpressed Flag tagged YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 and SRSF10 with 4-SU, the RNA bound by YTHDC1 and SRSF proteins can be got by Flag IP followed by RNA isolation by using the TRIzol (Invitrogen) reagent by following the company manual.the RNA was then used for library prep...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-71096 | biostudies-arrayexpress
GenomicsSRSF1 HITS-CLIP in MDA-LM2
SRSF1 HITS-CLIP in MDA-LM2
PRJNA544632 | ENA
TranscriptomicsGenome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing
SR proteins are well-characterized RNA binding proteins that promote exon inclusion by binding to exonic splicing enhancers (ESEs). However, it has been unclear whether regulatory rules deduced on model genes apply generally to activities of SR proteins in the cell. Here, we report global analyses o...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-44591 | biostudies-arrayexpress
TranscriptomicsTranscriptomics analysis of gene expression in normal and YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 or SRSF10 deficient human HeLa cells
RNA was isolated from and YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 and SRSF10 deficient human HeLa cells using the TRIzol (Invitrogen) reagent by following the company manual. For all samples the RNA integrity was checked using an Agilent Bioanalyzer 2100. All samples showed a RIN (RNA integrity number) o...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-71095 | biostudies-arrayexpress
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