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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
TranscriptomicsIdentification of candidate susceptibility and resistance genes of mice infected with Streptococcus suis type 2
There were four groups:control A/J mice;control B6 mice;SS2-infected A/J mice;SS2-infected B6 mice.The RNA samples of four groups were sent to Biostar Genechip Inc. (Shanghai, China) for microarray hybridization. The pooled RNA sample from each group was hybridized to one Illumina mouse Genome Beadc...
ORGANISM(S): Mus Musculus 
2012-02-09 | E-MTAB-745 | biostudies-arrayexpress
MetabolomicsMg2+ in drinking water exacerbates Salmonella Typhimurium T6SS-mediated intestinal bacterial competition through affecting metabolic reprogramming

By establishing a model of enteritis in mice infected with Salmonella Typhimurium, this study investigates the effects of ion concentration in drinking water on intestinal metabolites and microbiota structure in mice, as well as its influence on pathogen susceptibility and the host-patho...

2025-12-30 | MTBLS12690 | MetaboLights
GenomicsAliisedimentitalea sp. MJ-SS2
Aliisedimentitalea sp. MJ-SS2 Genome sequencing and assembly
PRJNA1024632 | ENA
GenomicsLacimicrobium sp. SS2-24
Lacimicrobium sp. SS2-24 Genome sequencing and assembly
PRJNA388364 | ENA
GenomicsAquimarina besae strain:SS2-1
Aquimarina besae strain:SS2-1 Genome sequencing
PRJNA1162685 | ENA
TranscriptomicsExpression data from Porcine alveolar macrophages of piglets experimentally infected with Streptococcus suis serotype 2 (SS2) for 7 days
Porcine alveolar macrophages (PAMs) play an important role in innate immunity. Streptococcus suis serotype 2 is a pathogen responsible for several diseases in both pigs and humans. We used microarrays to study the transcriptome of PAMs infected with SS2. Healthy pigs were inoculated intranasally wit...
ORGANISM(S): Sus scrofa 
2011-07-14 | E-GEOD-30696 | biostudies-arrayexpress
GenomicsClostridium sp. SS2/1
Reference genome for the Human Microbiome Project
PRJNA18201 | ENA
GenomicsAchromobacter sp. SS2-2022 isolate:enriched microbial community
Achromobacter sp. SS2-2022 isolate:enriched microbial community Genome sequencing
PRJNA878475 | ENA
GenomicsStreptococcus suis strain:SS2-1
Streptococcus suis SS2-1
PRJNA354204 | ENA
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