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ProteomicsSSR4 deficiency in B-cell reshapes the inflammatory microenvironment
The development and differentiation of infiltrating B cells influence the structure of the immune microenvironment (TIME). We aimed to unveil the impact of regulating B cell development and antibodies secretion by glycosylation modification-associated protein SSR4 on the formation of IME structures ...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD058527 | Pride
Mouse，b cells Ssr4 deficiency 
TranscriptomicsMethylation profiling by array of blood cells from patients with tartrate resistant acid phosphatase deficiency
The autosomal recessive immuno-osseus dysplasia spondyloenchondrodysplasia (SPENCD) is characterised by the variable combination of metaphyseal and vertebral bone lesions, immune dysfunction with features of both autoimmunity and immunodeficiency, and neurological involvement including developmental...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-MEXP-2699 | biostudies-arrayexpress
UnknownDeficient endoplasmic reticulum translocon-associated protein complex limits the biosynthesis of proinsulin and insulin.
Not available
S-EPMC8106808 | biostudies-literature
UnknownNovel genes underlying beta cell survival in metabolic stress.
Not available
S-EPMC3563414 | biostudies-literature
TranscriptomicsThe effect of HP1-gamma deficiency on primordial germ cells
We compared the gene expression profiles of the HP1 gamma -/- vs wild-type PGCs to examine the molecular mechanisms of HP1g in PGC development. Although HP1g is suggested to be involved in PGC proliferation, our microarray data indicated that HP1g does not directly control PGC cell-cycle progression...
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-27294 | biostudies-arrayexpress
TranscriptomicsMthfd1 is a modifier of intestinal carcinogenesis
The metabolic pathways that underlie the association between folate deficiency and increased risk for colorectal cancer (CRC) remain unclear. We have studied the effect of C1THF synthase (encoded by the Mthfd1 gene) and dietary folate and choline on intestinal tumor development in Apcmin/+ mice and ...
ORGANISM(S): Mus musculus 
2010-03-20 | E-GEOD-15419 | biostudies-arrayexpress
TranscriptomicsRegulation of hTERT by BCR-ABL at multiple levels in K562 cells
To investigate the mechanism of telomerase regulation in BCR-ABL positive cells due to its clinical value, we studied the catalytic component of telomerase, TERT. Our results suggest that BCR-ABL plays an important role in regulating hTERT in K562 (BCR-ABL positive human leukemia) cells. When Gleeve...
ORGANISM(S): Homo sapiens 
2011-12-15 | E-GEOD-26821 | biostudies-arrayexpress
TranscriptomicsWhole-genome hypothalamic transcriptome data collected from wild-type and ob/ob Pdyn-eGFP-RPL10a mice using BAC TRAP procedure
Prodynorphine-expressing neurons were targeted by eGFP-RPL10a, a transgene that is expressed under the control of the Pdyn promoter in a BAC containing the Pdyn backbone. Trangenic mice were made with FvB embryos via pro-nuclear injection. Transgene-positive progenies were bred to C57BL/6J for more ...
ORGANISM(S): Mus musculus 
2014-12-25 | E-GEOD-61436 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mosquitos fed blood infected with two alternative P. berghei strains: wild type (wt) or an invasion-deficient, CTRP (Circumsporozoite- and TRAP-related protein) knockout (ko) strain
Female mosquitoes fed with blood infected with two alternative P. berghei strains: wild type (wt) or an invasion-deficient, CTRP (Circumsporozoite- and TRAP-related protein) knockout (ko) strain. We used CTRPko-infected midguts as reference, as they experience pre-invasion conditions similar to thos...
ORGANISM(S): Anopheles gambiae 
2005-07-12 | E-MEXP-378 | biostudies-arrayexpress
TranscriptomicsRNAseq from macrophages and osteoclasts from wild-type and TRAP deficient bone cell reporter mice
Osteoclasts are multinucleated giant cells generated by the fusion of precursors in response to stimulation with macrophage colony stimulating factor (MCSF) and receptor activator of NF-kB ligand (RANKL). These cells are the only cells capable of resorbing bone. Tartarate-resistant acid phosphatase ...
ORGANISM(S): Mus musculus 
2024-02-02 | E-MTAB-11403 | biostudies-arrayexpress
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