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TranscriptomicsDifferential features of Aire-induced and Aire-independent promiscuous gene expression in thymic epithelial cells
Promiscuous gene expression (pGE) of numerous self-antigens in thymic epithelial cells (TEC) enables the elimination of self-reactive T cells. The autoimmune regulator (Aire) is the only known molecular determinant driving pGE in the thymus but the existence of Aire-independent mechanisms has been i...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-65617 | biostudies-arrayexpress
ProteomicsThe human spermatozoa proteome
The human spermatozoa proteome was in depth characterized using shotgun iterative GeLC-MS/MS method with peptide exclusion lists.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-06-26 | MSV000082508 | MassIVE
TranscriptomicsAtra effect on ERBB2 and RARA-coamplified SKBR-3 cells.
RNA was extracted with Rneasy Micro Kit (Qiagen, France) from SKBR3 cells treated with 1 uM ATRA. The quantity and purity of the extracted RNA was evaluated using a NanoDropTM spectrophotometer and its integrity measured using an Agilent BioanalyzerTM. For microarray hybridizations, 500 ng of total ...
ORGANISM(S): Homo sapiens 
2012-03-02 | E-MTAB-1013 | biostudies-arrayexpress
TranscriptomicsThe probiotic mixture VSL#3 has differential effects on intestinal immune parameters in healthy female BALB/c and C57BL/
Probiotic bacteria may render mice resistant to the development of various inflammatory and infectious diseases. This study aimed to identify underlying mechanisms by which probiotic bacteria may influence intestinal immune homeostasis in non-inflammatory conditions. To this end, we studied the effe...
ORGANISM(S): Mus musculus 
2014-10-23 | E-GEOD-62619 | biostudies-arrayexpress
OtherHuman spermatozoa as a model for detecting missing proteins in the context of the chromosome-centric Human Proteome Project.
Data from ProteomeXchange, PXD ID: PXD002367. File: Mitchell_40_F03_exclu02.mzml. Published as part of J Proteome Res. 2015 . From the Abstract: {{i}} The chromosome-centric Human Proteome Project (C-HPP) aims at cataloguing the proteins as gene products encoded by the human genome, in a chromosome...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320016359 | GPMDB
Resource Reanalysis 
TranscriptomicsTranscription profiling of Drosophila infected with Drosophila C virus reveals a third evolutionary conserved innate immunity pathway operates in drosophila and counters viral infection
The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate NF-kB family members. We have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct fr...
ORGANISM(S): Drosophila melanogaster 
2007-07-07 | E-GEOD-2828 | biostudies-arrayexpress
TranscriptomicsEarly dendritic cell molecular signature modelling predicts late vaccine-induced adaptive T-cell responses (Illumina)
Mice were vaccinated with different Lentivirus vector-plaforms or PBS. Transcriptomes of sorted dendritic cells 6 hours after vaccination were used to build a model predictive of the vector-platform efficacy measured as the antigen-specific response 5, 7 and 10 days after the vaccination Groups of 7...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-66797 | biostudies-arrayexpress
TranscriptomicsClariom S Microarray from gWAT RNA of female and male offspring of T3 treated and control dams
This study analysed the effect of maternal hyperthyroidism on the offspring’s white adipose tissue function. Hyperthyroidism during pregnancy was induced in wild type female C57BL/6NCrl (Charles River, Germany) at the age of three to four month with 0.5 mg/L T3 (3,3’,5-Triiodo-L-thyronine, T6397, Si...
ORGANISM(S): Mus musculus 
2024-12-30 | E-MTAB-14515 | biostudies-arrayexpress
ProteomicsQuest for missing proteins in the human spermatozoa: an update
Here, we report work as part of C-HPP initiatives on chromosomes 14 (France) and 2 (Switzerland) aiming to identify missing proteins in ejaculated human spermatozoa using multiple MS-based and antibodies-based validation approaches
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080826 | MassIVE
TranscriptomicsActivation of IFN/STAT1 signaling is a hallmark of response to chemotherapy in patient-derived xenografts of triple-negative breast cancer
By using patient-derived xenografts (PDXs) as living surrogate of the clinical practice, we identify here induction of genes related to the IFN pathway as an early and specific predictor of tumor response to treatment. Gene expression profile of tumor cells after laser-capture microdissection of res...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-58990 | biostudies-arrayexpress
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