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TranscriptomicsIn depth sequencing of the siRNAs associated with peach latent mosaic viroid infection
Using a high-throughput sequencing approach we quantitatively analyzed the content of viroid-derived siRNAs of an infected tree. Our results show that the entire PLMVd genome is found in the siRNA population. Also both polarities are susceptible to be targeted by the RNAi machinery but specific regi...
ORGANISM(S): Prunus persica 
2010-02-20 | E-GEOD-18764 | biostudies-arrayexpress
TranscriptomicsGene expression profile of calcified and normal tricuspid aortic valves by RNA sequencing.
Purpose: Calcific aortic valve stenosis (AS) is a fatal disease with currently no medical therapy. Some genes were associated with AS, but the genetic architecture of the disease has yet to be discovered. The objective of this study was to combine genome-wide association studies (GWAS) and gene expr...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-55492 | biostudies-arrayexpress
TranscriptomicsGene transcription profiling in wild and laboratory-exposed eels reveals common responses to low temperature and chronic pollution exposure
Aquatic ecosystems are subjected to a variety of man-induced stressors but also vary spatially and temporally due to variation in natural factors. In such complex environments, it remains difficult for ecotoxicologists to evaluate the effects of contaminants in wild organisms. The aim of the present...
ORGANISM(S): Anguilla anguilla 
2015-01-01 | E-GEOD-64170 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of differentiated brown adipocytes from wild type, PGC-1 alpha knockout, or PGC-1 alpha knockout and PGC-1 beta knockdown mice to investigate the roles of PGC-1 coactivators in brown fat differentiation.
Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lac...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5042 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human invasive and non-invasive non-functioning pituitary adenomas
Context : Non Functioning Pituitary Adenomas (NFPAs), although typically benign, may be locally invasive. Few datas are currently available related to the molecular process of invasion in sporadic pituitary adenomas. Markers of invasiveness, important for helping the clinician in the therapeutic s...
ORGANISM(S): Homo sapiens 
2010-03-18 | E-TABM-899 | biostudies-arrayexpress
TranscriptomicsHigh dietary protein decreases fat deposition induced by high-fat and high-sucrose diet in rats
High-protein diets are known to reduce adiposity in the context of high carbohydrate and Western diets. However, few studies have investigated the specific high-protein effect on lipogenesis induced by a high-sucrose (HS) diet or fat deposition induced by high-fat feeding. We aimed to determine the ...
ORGANISM(S): Rattus norvegicus 
2015-09-01 | E-GEOD-47570 | biostudies-arrayexpress
TranscriptomicsSmall RNA sequencing in Medicago truncatula roots (Glomus intraradices colonized and non-colonized)
Identification of microRNA expressed in M. truncatula roots Small RNA sequencing of mycorrhizal and non-mycorrhiza M. truncatula roots
ORGANISM(S): Medicago truncatula 
2011-06-16 | E-GEOD-26216 | biostudies-arrayexpress
TranscriptomicsDegradome sequencing in Medicago truncatula roots (Glomus intraradices colonized and non-colonized)
Identification of microRNA targets in M. truncatula roots Degradome sequencing of mycorrhizal and non-mycorrhiza M. truncatula roots
ORGANISM(S): Medicago truncatula 
2011-06-16 | E-GEOD-26217 | biostudies-arrayexpress
UnknownGenetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Not available
S-EPMC4879695 | biostudies-literature
TranscriptomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (2)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63234 | biostudies-arrayexpress
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