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UnknownPreclinical Development of Autologous Hematopoietic Stem Cell-Based Gene Therapy for Immune Deficiencies: A Journey from Mouse Cage to Bed Side.
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S-EPMC7357087 | biostudies-literature
TranscriptomicsTranscription profiling of FACS sorted mouse calvarial osteroblasts at defined differentiation stages to identify genes highly associated with osteoblast differentiation
This study compares a comprehensive microarray analysis of unsorted mCOB cultures at two level of cell differentiation with cells that are more homogeneous for a level of cellular differentiation. It demonstrates the loss of information and in some cases misinformation that occurs when a heterogeneo...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2332 | biostudies-arrayexpress
TranscriptomicsHigh levels of canonical Wnt signaling lead to loss of stemness and increased differentiation in hematopoietic stem cells
Canonical Wnt signalling regulates the self-renewal of most if not all stem cell systems. In the blood system, the role of Wnt signalling has been subject of much debate, with positive and negative roles of Wnt signalling proposed for hematopoietic stem cells (HSC). As we have shown previously, this...
ORGANISM(S): Mus musculus 
2016-03-23 | E-GEOD-79495 | biostudies-arrayexpress
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