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ProteomicsComparative platelet releasate proteome profiling of acute coronary syndrome versus stable coronary artery disease
Upon activation, platelets release a host of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). The contents of this PR play a significant role in haemostasis, inflammation, and pathologic sequelae. Despite this, proteomic studies investigating the PR in coronary arter...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD009356 | Pride
Platelet releasate Proteomics Platelets Acute coronary syndrome Stable coronary artery disease Lc-ms/ms 
TranscriptomicsCirculating Mononuclear Cell Transcriptomes in Patients with Atherosclerotic Coronary Artery Disease
Monocytes and T-cells play an important role in the development of atherosclerotic coronary artery disease (CAD). Differences in transcriptional activity of these cells might reflect the individual's atherosclerotic burden. Transcriptome analysis of circulating mononuclear cells from carefully match...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9820 | biostudies-arrayexpress
TranscriptomicsCoronary artery disease-associated genotype data in Mediterranean populations
We wanted to explore the genomic regions 1p13, 1q41, 9p21 and 10q11, which are among the labeled “top 12 golden loci” linked to coronary artery disease (CAD) risk, in order to see whether their geographic variation could be explained by demographic effects. To do this, we have genotyped these ri...
ORGANISM(S): Homo sapiens 
2016-11-24 | E-MTAB-5265 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis in Patients with Progressive Coronary Artery Disease
The identification of classic risk factors for coronary artery disease unveiled pathophysiologic mechanisms of atherosclerosis. Among them, inflammation as a systemic process measurable in peripheral blood plays a central role in plaque progression. However, other mechanisms of plaque progression re...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-34822 | biostudies-arrayexpress
TranscriptomicsGenome Wide Linkage analysis of large family with coronary artery disease
We used linkage data from CAD family to search for the responsible variant in disease. we used illumina array for linkage analysis of CAD affected family.
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-42137 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of CD133+ Cells in Coronary Artery Disease and Effects of Exercise on Gene Expression
Bone marrow-derived progenitor cells are under investigation for cardiovascular repair, but may be altered by disease. We identified 82 differentially expressed genes in CD133+ cells from patients with coronary artery disease (CAD) versus controls, of which 59 were found to be up-regulated and 23 do...
ORGANISM(S): Homo sapiens 
2010-12-17 | E-GEOD-18608 | biostudies-arrayexpress
TranscriptomicsDifferent gene expression profile in acute coronary sindrome (ACS) patients compared to stable angina(SA) patients.
We have employed whole genome microarray expression profiling as a discovery platform to identify genes involved in plaque rupture. Human coronary artery endothelial cells (ECs) were stimulated in vitro for 12 hours with plasma obtained from the coronary sinus (CS) and the aorta (Ao) of patients wit...
ORGANISM(S): Homo sapiens 
2014-02-14 | E-GEOD-54977 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to identify differential molecular signatures in subjects with stable coronary artery disease on standard dosage regimens versus healthy controls
In the present study, we used a top-down approach using microarray analysis to evaluate the novel molecular signatures that differentiate between subjects with stable coronary artery disease and normal healthy controls and which remain unresponsive to the standard therapies currently in clinical pra...
ORGANISM(S): Homo sapiens 
2015-04-16 | E-GEOD-56885 | biostudies-arrayexpress
TranscriptomicsMouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populations
The single-cell RNA-seq experiment aims to explore the cell-type composition of right coronary artery plaques to provide an overview of human-like atherosclerosis. The PCSK9 transgenic minipigs were subjected to 15 months of HFHC diet (HFHC group f, n=4; m, n=1). At the time of euthanasia, plaque pa...
ORGANISM(S): Sus scrofa 
2025-08-30 | E-MTAB-15464 | biostudies-arrayexpress
TranscriptomicsTo evaluate the effect of Terminalia arjuna as an adjuvant therapy in subjects with stable coronary artery disease on standard dosage regimens versus placebo
Terminalia arjuna (Roxb.) Wight & Arn., a well known Traditional medicine an. popularly known as Arjuna, has a long antiquity of its role as a cardiac stimulant, and has been stipulated in the treatment of hypercholesterolemia, heart failure and atherosclerosis. The present study was carried out to ...
ORGANISM(S): Homo sapiens 
2015-04-16 | E-GEOD-56886 | biostudies-arrayexpress
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