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MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
ProteomicsTranscriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration.
Induced pluripotent stem cells generated from patients with geographic atrophy as well as healthy individuals were differentiated to retinal pigment epithelium (RPE) cells. By integrating transcriptional profiles of 127,659 RPE cells generated from 43 individuals with geographic atrophy and 36 contr...
ORGANISM(S): Homo sapiens (Human) 
2022-06-01 | PXD029501 | Pride
Amd 
GenomicsdeCODE Genetics study on genes contributing to nicotine dependence in humans

A genome-wide association study on smoking behavior and nicotine dependence in Icelandic smokers, assessed by the number of cigarettes smoked per day, smoking initiation and degree of dependence on nicotine.

The number of cigarettes smoked per day was ascertained through questionnaires giv...

phs000393.v1.p1 | EGA
UnknownSequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.
Not available
S-EPMC3080612 | biostudies-literature
TranscriptomicsNuclear Factor κB inducing kinase activation as a mechanism of pancreatic beta cell failure in obesity
The NF-κB pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic beta cell dysfunction in the metabolic syndrome. While canonical NF-κB signaling is well studied, there is little information on the divergent non-canonical NF-κB pathway in the c...
ORGANISM(S): Mus musculus 
2015-06-18 | E-GEOD-68317 | biostudies-arrayexpress
UnknownCommon and Rare Sequence Variants Influencing Tumor Biomarkers in Blood.
Not available
S-EPMC6954334 | biostudies-literature
UnknownA Phase 3 Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of V116 in Pneumococcal Vaccine-Experienced Adults 50 Years of Age or Older (STRIDE-6).
Not available
S-EPMC11650886 | biostudies-literature
GenomicsA Genome-Wide Association Study of Peripheral Arterial Disease

The Electronic Medical Record Phenotypes and Community-engaged Genomic Association Study aims to identify genetic variants mediating susceptibility to peripheral arterial disease (PAD). The study leverages a biorepository of blood samples of 1688 PAD cases and 1649 controls, and the electronic ...

phs000203.v1.p1 | EGA
GenomicsMelanoma Genome Sequencing Project

Melanoma is the most prevalent cause of skin cancer morbidity and mortality. In order to characterize the full range of somatic mutations that may drive the growth of melanoma, we are sequencing tumor and normal DNA from a set of roughly 150 melanomas. For the majority of samples (approximately 9...

phs000452.v1.p1 | EGA
UnknownCommon variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
Not available
S-EPMC3664837 | biostudies-literature
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