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ProteomicsIn situ synthesis of peptide microarrays - shadow mask design
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50045 | biostudies-arrayexpress
ProteomicsIn situ synthesis of peptide microarrays - shadow mask design [1]
A computer program was used to create random amino acid sequences based on and restricted by physical shadow masks which will be used for lithography-based synthesis of peptides. The output from this algorithm was used to create peptides that were synthesized by Sigma Aldrich, and printed onto glas...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-49217 | biostudies-arrayexpress
ProteomicsIn situ synthesis of peptide microarrays - shadow mask design [3]
In this paper several computer programs were used to simulate in situ synthesis of peptides using shadow masks and BOC synthesis. The peptides were designed to be random, or pseudo-random, but fulfill requirements of immunosignaturing. This file contains data from actual 330,000 peptide arrays tha...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50571 | biostudies-arrayexpress
ProteomicsIn situ synthesis of peptide microarrays - shadow mask design [2]
An experiment was designed to use a computer program to create lithography masks using a pseudo-random pattern generator. The data in this file are results from immunosignaturing 8 different monoclonals using a 10,000 peptide random-sequence microarray. Peptides were synthesized by Sigma Aldrich, ...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50044 | biostudies-arrayexpress
ProteomicsSegmentation and intensity estimation for microarray images with saturated pixels
Images and gpr files were examined using a novel saturation reduction method to determine whether accuracy could be improved by extending dynamic range of saturated pixels Three immunosignatures from human Valley Fever (Coccidiodes) patients and three immunosignatures from human influenza vaccine re...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-33899 | biostudies-arrayexpress
TranscriptomicsPancreatic Tumor vs Various Tissue Normals
Pancreatic Tumor samples from biopsy collected at different stages along with normal tissue samples from various organ sites including commercial normals arrayed on 2channel Agilent 60mer Oligo arrays (human v1 & v2), median normalized for cross comparison. Some normal samples temporarily removed to...
ORGANISM(S): Homo sapiens 
2008-09-15 | E-GEOD-11838 | biostudies-arrayexpress
ProteomicsDiagnosis and early detection of CNS-SLE in MRL/lpr mice using peptide microarrays (GPL14921)
We investigated whether mouse serum autoantibody binding patterns on random-sequence peptide microarrays (immunosignaturing) can be used for diagnosing and predicting the onset of lupus and its central nervous system (CNS) manifestations. Submitter states "We have no processed data to submit. ...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-57388 | biostudies-arrayexpress
ProteomicsDiagnosis and early detection of CNS-SLE in MRL/lpr mice using peptide microarrays (GPL17600)
In addition to determining possible diagnostic and predictive peptides of lupus and CNS-lupus, we also used our microarray technology along with the Guitope computer program to determine possible natural protein match to five monoclonal autoantibodies that were created using one of the autoimmune MR...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-57389 | biostudies-arrayexpress
TranscriptomicsRNA expression analysis of cells producing the synthetic protein DX over a 4hr time course
We expressed the man-made protein DX in E. coli cells over the course of 4 hours and examined effects on global gene expression. We analyzed the change in RNA expression profiles of E. coli cells expressing the synthetic protein DX every half-hour over a four hour experiment. These samples were com...
ORGANISM(S): Escherichia coli 
2010-07-21 | E-GEOD-17568 | biostudies-arrayexpress
TranscriptomicsSpaceflight Modulates Gene Expression in Astronauts
Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to infectious pathogens. Here we report the first microarray evaluation of any astronaut tissue sample, specifically whole bl...
ORGANISM(S): Homo sapiens 
2013-10-15 | E-GEOD-47126 | biostudies-arrayexpress
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