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TranscriptomicsCytokines dominate the secretome of primary human myotubes in an in vitro exercise model
Muscle contraction during exercise is the major stimulus for the release of peptides and proteins (myokines) that are supposed to take part in the benefical adaptation to exercise. We hypothesize that application of an in vitro exercise stimulus as electric pulse stimulation (EPS) to human myotubes ...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-44051 | biostudies-arrayexpress
TranscriptomicsComparing the transcriptome profiling of ob/ob mice treated with the GLP-1 receptor agonist liraglutide, a clinically used GLP-1 receptor agonist, versus baseline controls
B6.Cg-Lep ob/ob mice females were surgically implanted in an age of 10-12 weeks with Alzet osmotic mini pumps (model 1002, 0,25l/h, Cupertino, CA, USA) in two groups of ten mice each to perform continuous subcutaneous infusions of Dulbecco's phosphate buffered saline (vehicle; n = 8) or GLP-1 (GLP-1...
ORGANISM(S): Mus musculus 
2017-09-03 | E-MTAB-6015 | biostudies-arrayexpress
TranscriptomicsFibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes
Background/aims: Serum concentrations of the hepatokine fibroblast growth factor (FGF) 21 are elevated in obesity, type‐2 diabetes, and the metabolic syndrome. We asked whether FGF21 levels differ between subjects with metabolically healthy vs. unhealthy obesity (MHO vs. MUHO) opening the possibilit...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-67279 | biostudies-arrayexpress
TranscriptomicsIdentification of proliferative and mature β-cells in the islet of Langerhans
Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential1-5, thus understanding the mechanisms underlying this functional heterogeneity ...
ORGANISM(S): Mus musculus 
2016-06-02 | E-GEOD-68853 | biostudies-arrayexpress
TranscriptomicsTGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle
substantial number of people at risk to develop type 2 diabetes could not improve insulin sensitivity by physical training intervention. We studied the mechanisms of this impaired exercise response in 20 middle-aged individuals who performed a controlled eight weeks cycling and walking training at 8...
ORGANISM(S): Homo sapiens 
2016-06-29 | E-GEOD-72462 | biostudies-arrayexpress
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