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TranscriptomicsTranscriptome profiling of hypoplastic and other intestinal mutants from the Liverplus Screen
Total RNA was extracted by Dr Joan Heath's team from morpholigcally abnormal and wildtype sibling zebrafish larvae of intestinal mutants initially identified in the Liverplus-Screen (Ober EA et al Nature 2006 PMID:16799568). The mutants have ZFIN Identifiers tti s450, set s453 and puck s456 (s: San ...
ORGANISM(S): Danio rerio 
2013-05-28 | E-ERAD-154 | biostudies-arrayexpress
ProteomicsStimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish
Cardiac metabolism plays a crucial role in producing sufficient energy to sustain cardiac function. However, the role of metabolism in different aspects of cardiomyocyte regeneration remains unclear. Working with the adult zebrafish heart regeneration model, we first find an increase in the levels o...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2020-07-13 | PXD016235 | Pride
Metabolism Cardiac regeneration Yebrafish 
TranscriptomicsGenome-wide analysis of gene expression and intron retention during development in a U12-type splicing-deficient zebrafish mutant [RNA-seq]
To determine the global impact of the clbn mutation on gene expression and efficiency of U2- and U12-type splicing, we analyzed the transcriptome of 108hpf wt and clbn mutant larvae by microarrays and RNA sequencing. RNAseq data was used to characterize intron retention of U2-type and U12-type intro...
ORGANISM(S): Danio rerio 
2014-02-05 | E-GEOD-53758 | biostudies-arrayexpress
TranscriptomicsEffect of from Human Umbilical Vein Endothelial Cells
We profiled global gene expression in primary human umbilical vein endothelial cells to determine the gene expression changes associated with knocking down PKM2 and p53. We identified a p53 dependent transcriptional response that remodels metabolism in cells lacking p53, thus limiting cell growth. H...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-84877 | biostudies-arrayexpress
Transcriptomicskdrl:eGFP+ ECs isolated from wildtype, etsrp-null, npas4l-null, and sox32-null zebrafish embryos
Microarray analysis of triplicate RNA samples isolated from kdrl:eGFP-sorted ECs of wildtype, npas4l-/-, etsrp-/-, and sox32-/- zebrafish embryos in Tg(kdrl:EGFP) transgenic background between 18 and 18.5 hpf.
ORGANISM(S): Danio rerio 
2020-10-20 | E-MTAB-9698 | biostudies-arrayexpress
TranscriptomicsZebrafish liver: Tg(fabp10a:pt-beta-catenin) versus non-transgenic control siblings
To investigate mechanisms by which activated β-catenin signaling promotes liver tumor formation and to identify potential therapeutics for these cancers, we generated transgenic zebrafish expressing hepatocyte-specific activated β-catenin (Tg(fabp10a:pt-β-cat) zebrafish. As adults, these animals sh...
ORGANISM(S): Danio rerio 
2015-04-30 | E-GEOD-68124 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression and intron retention during deveopment in a U12-type splicing-deficient zebrafish mutant [microarray]
To determine the global impact of the clbn mutation on gene expression and efficiency of U2- and U12-type splicing, we analyzed the transcriptome of 108hpf wt and clbn mutant larvae by microarrays and RNA sequencing. RNAseq data was used to characterize intron retention of U2-type and U12-type intro...
ORGANISM(S): Danio rerio 
2014-02-05 | E-GEOD-53934 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression and intron retention during development in a U12-type splicing-deficient zebrafish mutant
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Danio rerio 
2014-02-05 | E-GEOD-53935 | biostudies-arrayexpress
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