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TranscriptomicsMycobacterium smegmatis: CarD depletion (mgm1703) vs Control (mgm1701)
Transcriptional profiling of Mycobacterium smegmatis comparing the effects of wild type levels of CarD expression with CarD depletion. Transcriptional profile of the mgm1701 control strain was compared with that of mgm1703, a strain where CarD transcription is regulated by a Tet-On system. Both stra...
ORGANISM(S): Mycobacterium smegmatis 
2010-05-16 | E-GEOD-15437 | biostudies-arrayexpress
TranscriptomicsOligoarray comparative genomic hybridisation-mediated mapping of suppressors of an essential receptor tyrosine kinase generated in a deletion-biased mutagenesis screen
We have used oligoarray comparative genomic hybridization (aCGH) to identify novel suppressors generated in a UV-TMP based suppressor screen. This approach is suitable for detecting single gene mutations as well as copy number variations. Keywords: C.elegans Suppressor screen array CGH [1] 2 test s...
ORGANISM(S): Caenorhabditis elegans 
2012-07-12 | E-GEOD-15224 | biostudies-arrayexpress
GenomicsGenome-wide mapping of CarD, RNAPs, and RNAPb on the Mycobacterium smegmatis genome using Chromatin Immunoprecipitation Sequencing
CarD is an essential mycobacterial protein that we had previously shown to bind the RNA polymerase (RNAP) and affect the transcriptional profile of M. smegmatis and Mycobacterium tuberculosis. For this reason, we suspected that CarD was directly regulating transcriptional complexes but we did not kn...
ORGANISM(S): Mycobacterium smegmatis 
2013-08-01 | E-GEOD-48164 | biostudies-arrayexpress
UnknownThe Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.
Not available
S-EPMC4466081 | biostudies-literature
UnknownSelect autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes.
Not available
S-EPMC7147835 | biostudies-literature
MetabolomicsTranscriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models

Microorganisms can adopt a quiescent physiological condition which acts as a survival strategy under unfavourable conditions. Quiescent cells are characterized by slow or non-proliferation and deep down-regulation of processes related to biosynthesis. Although quiescence has been described mostly...

2022-02-23 | MTBLS4046 | MetaboLights
UnknownNon-viral precision T cell receptor replacement for personalized cell therapy.
Not available
S-EPMC9768791 | biostudies-literature
UnknownResponses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.
Not available
S-EPMC9334931 | biostudies-literature
UnknownCalcium/vitamin D supplementation and coronary artery calcification in the Women's Health Initiative.
Not available
S-EPMC2940244 | biostudies-literature
UnknownGlobal COVID-19 lockdown highlights humans as both threats and custodians of the environment.
Not available
S-EPMC8135229 | biostudies-literature
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