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TranscriptomicsTranscription profiling of human chronic lymphocytic leukemia cells treated with valproic acid
Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have recently been proposed as potential new therapies for hematological malignancies. Chronic Lymphocytic Leukemia (CLL) remains incurable despite the introduction of new treatments. CLL cells are characterized by an apoptosis ...
ORGANISM(S): Homo sapiens 
2009-09-17 | E-GEOD-14973 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chronic lymphocytic leukemia patients expressing high or low levels of ZAP70 mRNA
Comparison of Chronic Lymphocytic Leukemia patients expressing high or low levels of ZAP70 mRNA: prognostic factors and interaction with the microenvironment. Zeta-associated protein 70 (ZAP70) is a widely recognized prognostic factor in chronic lymphocytic leukemia (CLL), but mechanisms by which it...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-12734 | biostudies-arrayexpress
UnknownHighly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations.
Not available
S-EPMC5927998 | biostudies-literature
TranscriptomicsDNA methylation profiling of clinically aggressive chronic lymphocytic leukemia cases by Illumina 450k arrays
Chronic lymphocytic leukemia (CLL) stereotyped subsets #6 and #8 include cases expressing unmutated B cell receptor immunoglobulin (BcR IG) (U-CLL). Yet, subset #6 (IGHV1-69/IGKV3-20) is less aggressive compared to subset #8 (IGHV4-39/IGKV1(D)-39) which has the highest risk for Richter’s transformat...
ORGANISM(S): Homo sapiens 
2019-04-04 | E-MTAB-6955 | biostudies-arrayexpress
UnknownDistinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.
Not available
S-EPMC5472768 | biostudies-literature
TranscriptomicsDNA methylation analysis overtime in chronic lymphocytic leukemia cases treated with chemoimmunotherapy
The contribution of DNA methylation on the evolution of chronic lymphocytic leukemia has not been adequately studied yet. The purpose of this study was to investigate the role of DNA methylation in patients under chemoimmunotherapy. The overtime analysis of DNA methylation was performed on 40 patien...
ORGANISM(S): Homo sapiens 
2019-12-10 | E-MTAB-7575 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Chronic Lymphocytic Leukemia patients with and without t(14;19) samples, and normal mature B cells
Characterize the transcriptomes of CLL with and without t(14;19)
ORGANISM(S): Homo sapiens 
2026-07-14 | E-MTAB-15004 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of Chronic Lymphocytic Leukemia patients belonging to stereotyped subsets #6 and #8
Chronic lymphocytic leukemia (CLL) stereotyped subsets #6 and #8 include cases expressing unmutated B cell receptor immunoglobulin (BcR IG) (U-CLL). Yet, subset #6 (IGHV1-69/IGKV3-20) is less aggressive compared to subset #8 (IGHV4-39/IGKV1(D)-39) which has the highest risk for Richter’s transformat...
ORGANISM(S): Homo sapiens 
2019-04-04 | E-MTAB-6962 | biostudies-arrayexpress
UnknownCharacterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significance.
Not available
S-EPMC5141649 | biostudies-literature
UnknownBinding of CLL subset 4 B-cell receptor immunoglobulins to viable human memory B lymphocytes requires a distinctive IGKV somatic mutation.
Not available
S-EPMC5364113 | biostudies-literature
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