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TranscriptomicsSerum Conditions Do Not Abolish The Tumorigenicity of Glioma Stem Cells
The subset of GBM patient samples gives rise to adherent cultures even in sphere culture conditions. Most samples in this subset are tumorigenic and exhibit a hybrid expression profile when tested with the marker panel. Cultures from these samples have a predominantly mesenchymal character based on ...
ORGANISM(S): Homo sapiens 
2016-07-21 | E-GEOD-74571 | biostudies-arrayexpress
UnknownUltrasonic Surgical Aspirate is a Reliable Source For Culturing Glioblastoma Stem Cells.
Not available
S-EPMC5015049 | biostudies-literature
UnknownIdentification and characterization of a new source of adult human neural progenitors.
Not available
S-EPMC5596556 | biostudies-literature
UnknownDifferential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency.
Not available
S-EPMC5290038 | biostudies-literature
TranscriptomicsComparison study of glioma stem cells and adult human neural stem cells
Glioblastoma, the most common and malignant brain tumor, harbors stem-like cells that self-renew and propagate upon serial transplantation. Although they share functional, morphological and developmental similarities to adult brain neural stem cells, stem cell characteristic pathways contributing to...
ORGANISM(S): Homo sapiens 
2013-07-27 | E-GEOD-31262 | biostudies-arrayexpress
UnknownTargeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo.
Not available
S-EPMC4470057 | biostudies-literature
TranscriptomicsKnockdown of NAT12/NAA30 decreases glioblastoma stem cell growth and tumorigenicity by regulating hypoxia response, p-MTOR (Ser2448) and p53 pathway
Gene knockdown of NAT12/NAA30 led to decreased proliferation, sphere forming ability and mitochondrial hypoxia tolerance in the GSC T65 culture. Intracranial transplantation of these cells into SCID mice showed that the decreased NAT12/NAA30 expression correlated with the prolonged animal survival a...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-60706 | biostudies-arrayexpress
TranscriptomicsTargeting PBK/TOPK decreases growth and survival of glioblastoma stem cells in vitro and attenuates tumor growth in vivo
Gene knockdown of PBK led to decreased proliferation and sphere formation in the GSC cultures. Treatment of cells with different concentrations of HI-TOPK-032 almost completely abolished growth and proliferation and elicited a large increase in apoptosis Total RNA isolated from GSC cultures featuri...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-53800 | biostudies-arrayexpress
UnknownBrain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape.
Not available
S-EPMC12586139 | biostudies-literature
UnknownCombined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells.
Not available
S-EPMC4694895 | biostudies-literature
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