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TranscriptomicsAtp4b-Cre;Cdh1(fl/fl);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach vs. Atp4b-Cre;Cdh1(fl/+);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach microarray
We wished to investigate the role of E-cadherin loss in our mouse parietal cell/pre-parietal cell E-cadherin knock-out, p53 knock-out, oncogenic Kras induced model of gastric cancer. As such, we isolated RNA from stomach tissue from our E-cadherin knock-out model (Atp4b-Cre;Cdh1(fl/fl);Kras(LSL-G12D...
ORGANISM(S): Mus musculus 
2018-05-01 | E-MTAB-5833 | biostudies-arrayexpress
GenomicsEpigenetic profiling of EMT in pancreatic cancer cells (RNA-seq)
Epigenetic profiling of EMT in pancreatic cancer cells (RNA-seq)
PRJNA565267 | ENA
ProteomicsSenescent cancer-associated fibroblasts in pancreatic adenocarcinoma impair CD8+ T cell activation and limit responsiveness to immunotherapy in mice
Senescent cells within tumors and their stroma exert complex pro- and anti-tumorigenic functions, yet the potential for targeting such senescent cells for improved therapy remains largely unknown. Here, we uncover the presence of a senescent subset of cancer-associated fibroblasts (CAFs) within panc...
ORGANISM(S): Homo sapiens (Human) 
2024-06-24 | PXD053144 | Pride
: senescence Venetoclax Pancreatic ductal adenocarcinoma (pdac) Senolytics Cancer associated fibroblasts (cafs) Immunotherapy Abt-199 T cells 
TranscriptomicsExpression analysis of YAP and Angiomotin target genes
To assess changes in gene expression regulated by Yap1 or Angiomotin, either Yap1 or Angiomotin were knocked down in HEK293 cells using shRNA and expression was assessed by microarray analysis and compared to expression patterns of wildtype cells. Microarray analysis was performed to compare gene...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-49406 | biostudies-arrayexpress
TranscriptomicsSpontaneous cell competition in U2OS human osteosarcoma cells.
The study compares the transcriptional profiles of U2OS human osteosarcoma cells and those of two single-cell derived sub-lines carrying a stably integrated H2BmCherry (U2OS-R1) or H2B-YFP (U2OS-YFP) expression cassette. U2OS-R1 and U2OS-YFP cell spontaneously undergo apoptosis upon co-culture with...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-MTAB-3204 | biostudies-arrayexpress
TranscriptomicsHippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas
The Hippo signaling pathway has become recognized as a context-dependent regulator of cell proliferation, differentiation, and apoptosis in species ranging from Drosophila to human. In this study, we sought to understand whether Hippo signaling plays a role in pancreatic development and organ homeos...
ORGANISM(S): Mus musculus 
2013-02-14 | E-GEOD-44298 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Notch constitutive activation induced HCC in mice
Notch intracellular domain (NICD) is the active form of the Notch receptor. In this mouse model, NICD is inserted in the Rosa26 locus downstream of a loxP-STOP-LoxP (lsl) sequence and therefore NICD expression is dependant on Cre recombinase expression. These mice are crossed with the AFP-Cre strain...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-33486 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Notch constitutive activation in the liver of mice
Notch intracellular domain (NICD) is the active form of the Notch receptor. In this mouse model, NICD is inserted in the Rosa26 locus downstream of a loxP-STOP-LoxP (lsl) sequence and therefore NICD expression is dependant on Cre recombinase expression (Mono transgenic control Rosa26-lsl-NICD) . The...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-33560 | biostudies-arrayexpress
TranscriptomicsPdx1 maintains ?-cell identity and function by repressing an ?-cell program
To get a more complete picture of the transcriptional changes associated with Pdx1 loss in ?-cells, we conducted an mRNA microarray comparing normal islet ?-cells and a-cells to the reprogrammed cells from PKO mice. Islet beta cells are from mice which has a single copy of Pdx1 flox (Pdx1L/+) allele...
ORGANISM(S): Mus musculus 
2013-11-19 | E-GEOD-52258 | biostudies-arrayexpress
UnknownImpact of postoperative acute kidney injury in patients undergoing major gastrointestinal surgery on 1-year survival and renal outcomes: a national multicentre cohort study.
Not available
S-EPMC8759520 | biostudies-literature
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