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TranscriptomicsEscape from X chromosome inactivation occurs within topologically associated domains
The spatial proximity between regulatory elements and their target genes has a profound affect on gene expression. X Chromosome Inactivation (XCI) is an epigenetic process by which an entire chromosome is rendered, for the most part, transcriptionally silent. A few genes are known to escape XCI and ...
ORGANISM(S): Mus musculus 
2014-03-26 | E-GEOD-49111 | biostudies-arrayexpress
TranscriptomicsfourSig: A Method for Determining Chromosomal Interactions in 4C-Seq Data
The ability to correlate chromosome conformation and gene expression gives a great deal of information regarding the strategies used by a cell to properly regulate gene activity. 4C-seq is a relatively new and increasingly popular technology where the set of genomic interactions generated by a singl...
ORGANISM(S): Mus musculus 
2014-02-22 | E-GEOD-50907 | biostudies-arrayexpress
GenomicsRepression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development
Polycomb-repressive complex 2 (PRC2) catalyzes the methylation of histone H3 Lys27 (H3K27) and functions as a critical epigenetic regulator of both stem cell pluripotency and somatic differentiation, but its role in male germ cell development is unknown. Using conditional mutagenesis to remove the c...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-61902 | biostudies-arrayexpress
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