Sort   by:  
 Page size 
TranscriptomicsActivation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells
After immunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of immunoglobulin (Ig) genes in B cells, introducing mutations within the antigen binding V regions (somatic hypermutation, SHM) and double-strand DNA breaks (DSBs) into switch (S) regions, leading...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-24827 | biostudies-arrayexpress
TranscriptomicsTHE UBIQUITIN-SPECIFIC PROTEASE 18 CONTROLS MICROGLIA QUIESCENCE UNDER HOMEOSTATIC AND INFLAMMATORY CONDITIONS
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-61501 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to evaluate the function of USP18 in the mouse CNS
Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis, and as such they are crucially important for organ integrity. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, calle...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-61499 | biostudies-arrayexpress
TranscriptomicsTranscriptome-based profiling reveals a macrophage pedigree and identifies Irf8 as pivotal for macrophage homeostasis and function
Recent studies have shown that tissue macrophages (MF) arise from embryonic progenitors of the yolk sac (YS) and fetal liver and colonize the tissues before birth. Further studies have proposed that developmentally distinct tissue MF can be identified based on the differential expression of F4/80 an...
ORGANISM(S): Mus musculus 
2016-07-28 | E-GEOD-73125 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to evaluate the role of USP18 in primary microglia and the microglia cell line BV-2
Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis, and as such they are crucially important for organ integrity. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, calle...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-61500 | biostudies-arrayexpress
Sort   by:  
 Page size