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GenomicsEvaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias and copy number variation
Abstract: DNA methylation is an essential epigenetic modification that plays a key role associated with the regulation of gene expression during differentiation but in disease states such as cancer, the DNA methylation landscape is often deregulated. There are now numerous technologies available to...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-24546 | biostudies-arrayexpress
GenomicsBisulphite-sequencing of chromatin immunoprecipitated DNA (BisChiP-seq) directly informs methylation status
Bisulphite sequencing enables DNA methylation analysis of every cytosine residue. We have optimized conditions for combining chromatin immunoprecipation (ChIP) with high throughput bisulphite sequencing to study the relationship between histone modifications and DNA methylation. Paired-end bisulphit...
ORGANISM(S): Homo sapiens 
2012-01-18 | E-GEOD-30558 | biostudies-arrayexpress
GenomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [human ChIP-Seq]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-31216 | biostudies-arrayexpress
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [human]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-30405 | biostudies-arrayexpress
UnknownSomatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency.
Not available
S-EPMC7843233 | biostudies-literature
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [mouse]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Mus musculus 
2014-01-13 | E-GEOD-30406 | biostudies-arrayexpress
UnknownMultiplex melanoma families are enriched for polygenic risk.
Not available
S-EPMC7566496 | biostudies-literature
UnknownPresentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: A multi-centre prospective cohort study.
Not available
S-EPMC9678980 | biostudies-literature
UnknownValidity of the Brief Test of Adult Cognition by Telephone in Level 1 Trauma Center Patients Six Months Post-Traumatic Brain Injury: A TRACK-TBI Study.
Not available
S-EPMC8054514 | biostudies-literature
UnknownMachine learning driven prediction of cerebrospinal fluid rhinorrhoea following endonasal skull base surgery: A multicentre prospective observational study.
Not available
S-EPMC10076706 | biostudies-literature
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