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MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
MetabolomicsUnraveling the Heterogeneity of Hyperuricemia Using Untargeted Metabolomics and Statistical Modeling

Background. Hyperuricemia is the second most prevalent metabolic disorder globally and exhibits pronounced heterogeneity in clinical practice. Only about 10% of individuals with asymptomatic hyperuricemia (HUA) progress to gout, yet the lack of specific biomarkers and precise therapeutic targets ...

2025-10-05 | MTBLS13094 | MetaboLights
MetabolomicsA statistical analysis of the effects of urease pre-treatment on the measurement of the urinary metabolome by gas chromatography–mass spectrometry
Urease pre-treatment of urine has been utilized since the early 1960s to remove high levels of urea from samples prior to further processing and analysis by gas chromatography–mass spectrometry (GC–MS). Aside from the obvious depletion or elimination of urea, the effect, if any, of urease pre-treatm...
2014-05-21 | MTBLS71 | MetaboLights
MetabolomicsOsmolality-based normalization enhances statistical discrimination of untargeted metabolomic urine analysis: results from a comparative study

INTRODUCTION: Because of its ease of collection, urine is one of the most commonly used matrices for metabolomics studies. However, unlike other biofluids, urine exhibits tremendous variability that can introduce confounding inconsistency during result interpretation. Despite man...

2023-09-04 | MTBLS1765 | MetaboLights
MetabolomicsExperiment design beyond gut feeling: statistical tests and power to detect differential metabolites in mass spectrometry data
We use metabolite profiles of the model plant Arabidopsis thaliana measured on an UPLC-ESI/QqTOF-MS as a pilot study to estimate variance levels which then can be used to obtain several statistical parameters (e.g. minimum detectable effect, number of required replicates and error probabilities) whi...
2014-11-06 | MTBLS74 | MetaboLights
MetabolomicsA statistical analysis of the effects of urease pre-treatment on the measurement of the urinary metabolome by gas chromatography–mass spectrometry
Not available
ORGANISM(S): Homo sapiens 
ST000092 | MetabolomicsWorkbench
MetabolomicsSeawater Analysis by Ambient Mass Spectrometry-Based Seaomics

A transmission mode-direct analysis in real time-quadrupole time of flight-mass spectrometry (TM-DART-QTOF-MS)-based analytical method coupled to multivariate statistical analysis was developed to interrogate lipophilic compounds in seawater samples without the need of desalin...

2020-05-19 | MTBLS1198 | MetaboLights
ProteomicsStatistical models for the analysis of isobaric Tags multiplexed quantitative proteomics
ABSTRACT: Mass spectrometry is being used to identify protein biomarkers that can facilitate development of drug treatment. Mass spectrometry based proteomics results in complex proteomic data that is hierarchical in nature often with small sample size studies. Generalized linear models (GLM) is th...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2017-07-28 | PXD005486 | Pride
Statistical models : proteomics Tmt Mixed models Biomarkers 
MetabolomicsMetabolomics Analysis of Limoniastrum monopetalum Extract

Limoniastrum monopetalum is a halophytic plant traditionally used in folk medicine for its purported antioxidant, antimicrobial, and anti-inflammatory properties. However, its chemical composition and bioactive constituents remain insufficiently characterized. In this study, we employed an untarg...

2025-08-25 | MTBLS12880 | MetaboLights
MetabolomicsData processing, multi-omic pathway mapping, and metabolite activity analysis using XCMS Online

Systems biology is the study of complex living organisms, and as such, analysis on a systems-wide scale involves the collection of information-dense data sets that are representative of an entire phenotype. To uncover dynamic biological mechanisms, bioinformatics tools have become essential to fa...

2017-11-23 | MTBLS572 | MetaboLights
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