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TranscriptomicsmiRNA profiling of 36 cases of diffuse large B cell lymphoma
miRNA expression data from 36 cases of RCHOP treated DLBCL samples were correlated with clinical variables in order to find miRNA signatures related with outcome. Cases classified according to the cell of origin classsifer (Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene express...
ORGANISM(S): Homo sapiens 
2011-08-01 | E-GEOD-21848 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of 29 cases of diffuse large B cell lymphoma
29 cases of RCHOP treated DLBCL were profiled for miRNA expression. Different integrated annalysis were performed, including mirNA differential expression between cases classified according to the COO signature (see later) and correlation tests between gene and miRNA expression. Cases classified acc...
ORGANISM(S): Homo sapiens 
2011-08-01 | E-GEOD-21847 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 29 cases of diffuse large B cell lymphoma
29 cases of RCHOP treated DLBCL were profiled for gene expression. Different integrated annalysis were performed, including mirNA differential expression between cases classified according to the COO signature (see later) and correlation tests between gene and miRNA expression. After transcriptional...
ORGANISM(S): Homo sapiens 
2011-08-01 | E-GEOD-21846 | biostudies-arrayexpress
TranscriptomicsEssential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse larg...
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-41034 | biostudies-arrayexpress
TranscriptomicsRibosomal protein S3: a functional component of NF-kB p65 binding complexes
To explore the effects on the NF-kB transcriptome after knockdown of RPS3 in stimulated T cells, we performed microarray assays comparing RPS3-silenced versus NS-treated samples on the same chip. p65-silenced versus NS-treated samples were used as a control. Keywords: time series design Jurkat cells...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-7231 | biostudies-arrayexpress
TranscriptomicsMyeloma IRF4 target genes - Agilent
The goal of this gene expression study was to identify genes whose expression depends on the transription factor IRF4 by knocking down it's expression using shRNA in two IRF4+ myeloma cell lines. Keywords: time series design Two myeloma lines were analyzed over a time course of IRF4-targeted shRNA i...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9067 | biostudies-arrayexpress
GenomicsIRF4 ChIP-on-chip for Myeloma Cell Lines
To identify IRF4 transcription factor binding on chromatin at 5' regulatory regions of genes in myeloma cell line models. Keywords: binding site identification design Formaldehyde cross-linked, sonicated chromatin is prepared from cell lines Kms12 (test) and Ly19 (control). Chromatin immunoprecipate...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-9367 | biostudies-arrayexpress
TranscriptomicsIRF4 and Myeloma
Using RNA interference to identify IRF4 target genes. Keywords: time series design Gene expression was analyzed using Lymphochip cDNA spotted arrays. Myeloma cell lines were infected with control (shluc, Cy3) or shIRF4 (Cy5) constructs, and changes in gene expression were monitored over time after i...
ORGANISM(S): Homo sapiens 
2008-07-07 | E-GEOD-8958 | biostudies-arrayexpress
TranscriptomicsCompensatory IKKa activation of classical NF-kB signaling during IKKb inhibition
A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive NF-kB pathway signaling for survival. Small molecule inhibitors of IkB kinase b (IKKb), a key regulator of the NF-kB pathway, kill ABC DLBCL cells and hold promise for the treatment ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-11902 | biostudies-arrayexpress
TranscriptomicsCooperative Signaling Through the STAT3 and NF-kB Pathways in Subtypes of DLBCL
The activated B cell-like (ABC) subgroup of diffuse large B cell lymphoma (DLBCL) is characterized by constitutive activation of the NF-êB pathway. Here we show that the NF- êB pathway induces the expression of the cytokines IL-6 and IL-10 in ABC DLBCL cell lines, which also have high levels of to...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-10009 | biostudies-arrayexpress
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