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GenomicsMulti-kinase inhibition of STE20 kinases is neuroprotective against chemotherapy-induced axon degeneration
Multi-kinase inhibition of STE20 kinases is neuroprotective against chemotherapy-induced axon degeneration
PRJNA1269058 | ENA
UnknownCrystal structure of domain-swapped STE20 OSR1 kinase domain.
Not available
S-EPMC2708061 | biostudies-literature
TranscriptomicsMulti-kinase inhibition of STE20 kinases is neuroprotective against chemotherapy-induced axon degeneration
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating condition resulting from the toxic action of cancer therapies on peripheral neurons. CIPN features axon terminal retraction from target organs leading to a myriad of sensory symptoms such as mechanical and thermal insensitivity, tin...
ORGANISM(S): Homo sapiens 
2025-10-17 | GSE298389 | GEO
GenomicsExon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1 mediated Phosphoenolpyruvate Production
Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1 mediated Phosphoenolpyruvate Production
PRJNA1273951 | ENA
ProteomicsSilencing of STE20-Type Kinase STK25 in Human Aortic Endothelial and Smooth Muscle Cells is Atheroprotective
Recent studies highlight the importance of lipotoxic damage in aortic cells as the major pathogenetic contributor of atherosclerotic disease. Since the STE20-type kinase STK25 has been shown to exacerbate ectopic lipid storage and associated cell injury in several metabolic organs, we here investiga...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031763 | Pride
Atherosclerosis  stk25  lipid accumulation  calcification  phenotypic switch 
UnknownSmad inhibition by the Ste20 kinase Misshapen.
Not available
S-EPMC3131379 | biostudies-literature
UnknownComprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.
Not available
S-EPMC6445471 | biostudies-literature
UnknownMARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1.
Not available
S-EPMC204455 | biostudies-literature
UnknownActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
Not available
S-EPMC162144 | biostudies-literature
UnknownDomain-Swapping Switch Point in Ste20 Protein Kinase SPAK.
Not available
S-EPMC5167558 | biostudies-literature
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