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TranscriptomicsRegulation of gene expression in murine liver by IL-6
STEAP4 is a plasma membrane metallo-reductase involved in the transport of iron and copper. Recently, STEAP4 was implicated in promoting insulin sensitivity by acting in white adipose tissue (WAT) to control the production of inflammatory cytokines such as IL-6. Indeed, the loss of STEAP4 expression...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-21060 | biostudies-arrayexpress
GenomicsAdipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice
Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice
PRJNA1037060 | ENA
ProteomicsSteap4 controls adipocyte thermogenesis and energy expenditure by modulating mitochondrial function
Steap4, a highly expressed protein in adipose tissue, has been implicated in metabolic homeostasis. In this study, we generated adipocyte-specific Steap4-deficient mice and observed that Steap4 deficiency led to increased fat mass and severe insulin resistance in a high-fat diet model. Mass spectrom...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-03 | PXD046997 | Pride
Adipose Steap4 Ip-ms 
TranscriptomicsAdipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice
Steap4, highly expressed in adipose tissue, is associated with metabolic homeostasis. Dysregulated adipose and mitochondrial metabolism contribute to obesity, highlighting the need to understand their interplay. Whether and how Steap4 influences mitochondrial function, adipocytes, and energy expendi...
ORGANISM(S): Mus musculus 
2025-02-03 | GSE247291 | GEO
ProteomicsEnhanced STEAP4 ubiquitination in Obesity: Insights from Integrated Proteome and Ubiquitylome Analysis of Visceral Adipose Tissue
We obtained the global proteomic and ubiquitylomic data of epididymal VAT from lean and obese male mice by mass spectrometry. Our proteomic analyses revealed significant changes of metabolic pathways involved in fatty acid, acyl-CoA and branched chain amino acids metabolism in obese VAT. Intriguingl...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-23 | PXD060435 | Pride
Ubiquitylome Obesity Steap4 Proteome 
ProteomicsDiscovery and pharmacological evaluation of STEAP4 as a novel target for HER2 overexpressing Breast cancer
The HER2 overexpressing and the Triple Negative Breast Cancer forms (TNBC) remain the most aggressive subtypes of BC with poor prognosis, frequent disease relapse and metastasis. In this study the aim was to identify key membrane-associated proteins which are overexpressed in these aggressive BC sub...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD021819 | Pride
Breast cacner Therapeutic targets Human Steap4 Orbitrap Her2 
UnknownThe STEAP4 target NQO1 mediates colon tumorigenesis.
Not available
S-EPMC12148032 | biostudies-literature
UnknownAdipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice.
Not available
S-EPMC11848796 | biostudies-literature
UnknownTumor Heterogeneity of STEAP4 in Malignant Progression of Oral Squamous Cell Carcinoma.
Not available
S-EPMC11632996 | biostudies-literature
UnknownOverexpression of goat STEAP4 promotes the differentiation of subcutaneous adipocytes.
Not available
S-EPMC9673034 | biostudies-literature
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