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ProteomicsIntegrated Fibre-Specific Methylome and Proteome Profiling of Human Skeletal Muscle Across Males and Females with Fibre-Type Deconvolution.
We simultaneously extracted DNA and protein from >200 single fibres per participant (7 males, 5 females) to directly compare methylome and proteome profiles of Type I and Type II human skeletal muscle fibres. Using the EPICv2 array and LC-MS/MS, we identified 5,689 robust DMRs (FDR <0.001) and 338 D...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD066393 | Pride
Human skeletal muscle  muscle fibres  type i (slow-twitch)  type ii (fast-twitch)  dna methylation  proteome  lc-ms/ms  epicv2 infinium array  deconvolution  myometh  myotype. 
ProteomicsGOT1 inhibition induces extracellular matrix remodeling in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) cells rely on glutamine to sustain their survival and growth in their stiff, hypoxic tumour microenvironment (TME). Inhibiting the glutamate oxaloacetate transaminase 1 (GOT1) enzyme is a promising strategy to target glutamine metabolism and impair PDAC cell f...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD065374 | Pride
ProteomicsHypoxic injury triggers maladaptive repair in human kidney organoids
Reduction in blood supply to the kidneys occurs to certain extent during kidney injury (AKI). Individuals who suffered AKI are at risk of developing chronic kidney disease (CKD) through a maladaptive repair process. At present, no therapies exist to prevent the AKI to CKD transition. Here, we presen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-26 | PXD042882 | Pride
Acute kidney injury Metabolomics Organoids Chronic kidney disease Transcriptomics Maladaptive regeneration Proteomics Hypoxia 
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