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TranscriptomicsTranscription profiling of human Ewing sarcoma (A673) cells treated with cytarabine, doxorubicin and puromycin oral tongue squamous cell carcinomas to identify novel potential prognosticators
An increasing number of cancer-associated mutations have been identified. Unfortunately, little therapy today exploits these tumor-specific genetic lesions. Often, the resulting oncoproteins have been intractable to easy manipulation with current small molecule screening approaches. To overcome this...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-6930 | biostudies-arrayexpress
TranscriptomicsTargeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to direct clinical translation have been lacking. We conducted a cell-based screen of genetically-defined cancer cell lines using a prototypica...
ORGANISM(S): Homo sapiens 
2013-02-25 | E-GEOD-43392 | biostudies-arrayexpress
UnknownMUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells.
Not available
S-EPMC3907758 | biostudies-literature
ProteomicsMudPIT analysis of STRN4 interacting proteins from HEK TER cells expressing either SV40 ST or GFP
HEK TER cells expressing either SV40 ST or GFP (30 x 15-cm diameter plates) were harvested with lysis buffer (20 mM imidazole HCl, 2 mM EDTA, 2 mM EGTA, pH 7.0 with 10 ug/mL each of aprotinin, leupeptin, pepstatin, 1 mM benzamidine, and 1 mM PMSF). The clarified cell extract was incubated overnight ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-12-05 | MSV000084662 | MassIVE
ProteomicsSND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
Schmidt N, Ganskih S, Wei Y, Gabel A, Zielinski S, Keshishian H, Lareau CA, , Zimmermann L, Makroczyova J, Pearce C, Krey K, Henig T, Stegmaier S, Moyon L, Horlacher M, Werner S, Aydin J, Olguin-Nava M, Potabattula R, Kibe A, Dölken L, Smyth RP, Caliskan N, Marsico A, Krempl C, Bodem J, Pichlmair A,...
ORGANISM(S): Sars Coronavirus (ncbitaxon:227859) Homo Sapiens (ncbitaxon:9606) 
2022-11-09 | MSV000090682 | MassIVE
UnknownMendelian randomization analysis of C-reactive protein on colorectal cancer risk.
Not available
S-EPMC6659358 | biostudies-literature
TranscriptomicsExpression data for developing a GE-HTS signature for neuroblastoma differentiation
Gene expression data from BE(2)-C cells treated in triplicate with either vehicle (DMSO), 5 M-NM-
ORGANISM(S): Homo sapiens 
2013-04-08 | E-GEOD-45587 | biostudies-arrayexpress
GenomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ChIP-seq]
In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates. As a proto-oncogene, targeted MYCN overexpression i...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80151 | biostudies-arrayexpress
TranscriptomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ATAC-seq]
In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates1,2. As a proto-oncogene, targeted MYCN overexpressio...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80152 | biostudies-arrayexpress
UnknownExploiting Nanoscale Complexion in LATP Solid-State Electrolyte via Interfacial Mg2+ Doping.
Not available
S-EPMC9457643 | biostudies-literature
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