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ProteomicsQuantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity. Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited nu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-10-07 | MSV000084429 | MassIVE
OtherDigestion and depletion of abundant proteins improves proteomic coverage.
Data from Yates lab web site. Experiment: yeast control replicate 2, file: 120211_Yeast_Control2_Step02.mzml. Published as part of Nat Methods. 2013 Jan;10(1):54-6 9 . From the Abstract: {{i}} We exploited the abundance-dependent Michaelis-Menten kinetics of trypsin digestion to selectively digest ...
ORGANISM(S): Yeast 
GPM32320001404 | GPMDB
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