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GenomicsIdentification of Biologically Relevant Enhancers in Human Erythroid Cells [ChIP-Seq]
Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypo...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43625 | biostudies-arrayexpress
GenomicsCTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells [ChIP-Seq]
CTCF and cohesinSA-1 are regulatory proteins involved in a number of critical cellular processes including transcription, maintenance of chromatin domain architecture, and insulator function. To assess changes in the CTCF and cohesinSA-1 interactomes during erythropoiesis, chromatin immunoprecipitat...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-67783 | biostudies-arrayexpress
TranscriptomicsThe histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation
The chromatin modifying enzymes that drive the erythroid-specific transcription program are incompletely understood. Setd8 is the sole histone methyltransferase in mammals capable of generating mono-methylated histone H4 lysine 20 (H4K20me1) and is expressed at significantly higher levels in erythro...
ORGANISM(S): Mus musculus 
2015-04-24 | E-GEOD-62647 | biostudies-arrayexpress
TranscriptomicsPatterns of histone H3 Lysine 27 monomethylation and erythroid cell-type specific gene expression [expression]
ERYTHROID CELL-TYPE SPECIFIC GENE EXPRESSION Post-translational histone modifications, acting alone or in a context-dependent manner, influence numerous cellular processes via their regulation of gene expression. Monomethylation of histone H3 lysine 27 (K27me1) is a poorly understood histone modific...
ORGANISM(S): Homo sapiens 
2011-12-06 | E-GEOD-32135 | biostudies-arrayexpress
TranscriptomicsIdentification of Biologically Relevant Enhancers in Human Erythroid Cells [Illumina BeadArray]
Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypo...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43624 | biostudies-arrayexpress
GenomicsGenome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation
Erythropoiesis is dependent on the activity of transcription factors, including the erythroid-specific erythroid Kruppel-like factor (EKLF). ChIP followed by massively parallel sequencing (ChIP-Seq) is a powerful, unbiased method to map transfactor occupancy. We used ChIP-Seq to study the interactom...
ORGANISM(S): Mus musculus 
2013-06-17 | E-GEOD-48020 | biostudies-arrayexpress
TranscriptomicsCTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells [RNA-Seq]
CTCF and cohesinSA-1 are regulatory proteins involved in a number of critical cellular processes including transcription, maintenance of chromatin domain architecture, and insulator function. To assess changes in the CTCF and cohesinSA-1 interactomes during erythropoiesis, chromatin immunoprecipitat...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-67892 | biostudies-arrayexpress
UnknownGlobal, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Not available
S-EPMC4561509 | biostudies-literature
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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