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TranscriptomicsHDAC3 modulates enhancer activity to regulate terminal B cell differentiation
B220+GL7+ (GC) and B220+GL7- (non-GC) B cells were sorted from SRBC-immunized mice deficient for Hdac3 and wild type controls. RNA-sequencing revealed an upregulation of critical regulators of B cell differentiation in Hdac3-deleted animals. 10 days post-immunization with SRBCs, GC and non-GC B cell...
ORGANISM(S): Mus musculus 
2016-09-02 | E-GEOD-77113 | biostudies-arrayexpress
TranscriptomicsHistone Deacetylase 3 is required for efficient T cell development
Hdac3 is an important target of HDAC inhibitors used in the treatment of cutaneous T cell lymphoma. In order to gain an understanding of Hdac3 function in T cells,we deleted Hdac3 from early mouse thymocytes using LCK-Cre. Hdac3 deletion resulted in a loss of single positive thymocytes due to a def...
ORGANISM(S): Mus musculus 
2015-09-11 | E-GEOD-72917 | biostudies-arrayexpress
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