HDAC3 modulates enhancer activity to regulate terminal B cell differentiation

ABSTRACT: B220+GL7+ (GC) and B220+GL7- (non-GC) B cells were sorted from SRBC-immunized mice deficient for Hdac3 and wild type controls. RNA-sequencing revealed an upregulation of critical regulators of B cell differentiation in Hdac3-deleted animals. 10 days post-immunization with SRBCs, GC and non-GC B cells were sorted and RNA isolated by Trizol extraction for RNA-sequencing. 2 replicates were sequenced for each condition.

ORGANISM(S): Mus musculus

SUBMITTER: Scott Hiebert 

PROVIDER: E-GEOD-77113 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress