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TranscriptomicsTranscriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer fatalities in Western societies, characterized by high metastatic potential and resistance to chemotherapy. Critical molecular mechanisms of these phenotypical features still remain unknown, thus hampering the development ...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-59761 | biostudies-arrayexpress
TranscriptomicsIdentification of drought stress related genes in NatA depleted mutants
N-terminal protein acetylation is one of the most common protein modifications in eucaryotes and is catalyzed co-translationally by N-terminal aceytltransferases (Nats). Regarding the number of predictaed substrates, NatA is the main Nat complex in human and yeast and is composed of the catalytic su...
ORGANISM(S): Arabidopsis thaliana 
2015-07-23 | E-GEOD-65414 | biostudies-arrayexpress
TranscriptomicsFIR inhibition in HCC cells (Hep3B)
siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA Together with far upstream element binding protein (FBP), the FBP-interacting repressor (FIR) represents a molecular tool for the transcriptional fine tune regulation of target genes. Previous evidence in...
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-55692 | biostudies-arrayexpress
MetabolomicsMonounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients
Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to ...
2014-06-17 | MTBLS92 | MetaboLights
TranscriptomicsTransforming growth factor beta-like stimulated clone 22 D4 promotes diabetic hyperglycemia and insulin resistance [abdominal fat]
Obesity-related insulin resistance represents the core component of the so-called Metabolic Syndrome, ultimately promoting glucose intolerance, pancreatic beta cell failure, and overt type 2 diabetes 1 2. Based on substantial side effects of existing pharmacological approaches, efficient and safe in...
ORGANISM(S): Mus musculus 
2014-10-15 | E-GEOD-53753 | biostudies-arrayexpress
TranscriptomicsCachexia-inducible Transforming growth factor-beta1 stimulated Clone-22 D4 controls acute hepatic lipid homeostasis.
To explore the molecular basis for TSC22D4 function in hepatic lipid homeostasis in vivo TSC22D4 was knocked down in the mouse liver using adenovirus and performed genome wide expression analysis. 1x10^9 plaque-forming units (pfu) per recombinant virus were administered via tail vein injection. Mice...
ORGANISM(S): Mus musculus 
2012-09-01 | E-GEOD-33324 | biostudies-arrayexpress
TranscriptomicsTranscriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue
Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of lipolysis has been studied in detail, the transcriptional determinants of WAT lipolytic activity remain still largely unexplored. Here we show that ...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-43658 | biostudies-arrayexpress
TranscriptomicsYAP Inhibition in HCC cells (Hep3B)
siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA. Loss of contact inhibition and anchorage-independent growth are hallmarks of cancer cells. In this context, frequent inactivation of the Hippo pathway and subsequent nuclear enrichment of the transcripti...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-35004 | biostudies-arrayexpress
Transcriptomicsmicro RNA-379 couples glucocorticoid hormones to metabolic dysfunction in diabesity
In metabolic control, GC signaling acts as a major counter-regulatory system against insulin action, and aberrantly elevated GC activity is tightly linked to major components of the so-called Metabolic Syndrome, including obesity, insulin resistance, hyperglycemia, and systemic dyslipidemia. Here we...
ORGANISM(S): Mus musculus 
2014-10-15 | E-GEOD-55245 | biostudies-arrayexpress
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