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MetabolomicsMetabolomics analysis of liver reveals profile disruption in bovines upon steroid treatment
INTRODUCTION: The surveillance of illegal anabolic practices in bovine meat production is necessary to guarantee consumers’ health. Screening strategies based on the recognition of indirect biological effects are considered by the community as promising tools to overcome some limitations of classica...
2018-05-08 | MTBLS436 | MetaboLights
ProteomicsRing A cleaving beta-diketon hydrolase is a key enzyme of steroid degradation in anaerobic bacteria
Bacterial degradation of the ubiquitous and persistent steroids is important for their removal from the environment, particularly for the endocrine disrupting steroid sex hormones. While aerobic bacteria use oxygenases to attack non-activated C-H/C-C bonds of the isoprenoid side chain or the steran ...
ORGANISM(S): Sterolibacterium denitrificans 
2025-05-07 | PXD053345 | Pride
Steroid degradation Lc-ms Hydrolase Sterolibacterium denitrificans 
TranscriptomicsTranscription array by profiling in WT and SRC-2 null mouse liver
The molecular targets of SRC-2 regulation in the murine liver stimulate fatty acid degradation and glycolytic pathway while fatty acid, cholesterol, and steroid biosynthetic pathways are down-regulated. A genomic approach using microarray analysis was employed to identify the subsets of genes that a...
ORGANISM(S): Mus musculus 
2014-02-14 | E-GEOD-55002 | biostudies-arrayexpress
ProteomicsWild type enrichment of a 25-phospho-steroid kinase involved in anaerobic steroid degradation
The anaerobic degradation of cholesterol fundamentally differs from the cytochrome P450 monooxygenase dependent activation of the isoprenoid side chain at C26 in aerobes. In the denitrifying β-proteobacterium Sterolibacterium denitrificans, activation of primary C26 proceeds via a three-step cascade...
ORGANISM(S): Sterolibacterium denitrificans 
2022-02-17 | PXD027031 | Pride
Cholesterol Steroid degradation Kinase 
TranscriptomicsEffect of AMPK activation by AICAR on MA-10 Leydig cell transcriptome
Steroid hormones regulate essential physiological processes and inadequate levels are associated with various pathological conditions. In testosterone-producing Leydig cells, steroidogenesis is strongly stimulated by LH via its receptor leading to increased cAMP production and expression of the ster...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-50118 | biostudies-arrayexpress
TranscriptomicsRole of Adrenal Steroid Metabolites in Osteoporosis in Patients with Autonomous Cortisol Secretion
Background: Autonomous cortisol secretion (ACS), results from cortisol-producing adenomas (CPA), causes endogenous steroid-induced osteoporosis (SIOP). However, how other adrenal steroid metabolites affect bone status is unclear. Methods: ACS was diagnosed at serum cortisol after 1-mg dexamethasone ...
ORGANISM(S): Homo sapiens 
2023-06-01 | E-MTAB-12895 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of zebrafish embryos after 96 h exposure to two subsequent concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12β-trihydroxy-androsta-4,6-diene-3,17-dione (THADD)
The aim of this mRNA expression profiling experiment was to screen for ecotoxicogenomic fingerprints in zebrafish (Danio rerio) embryos as aquatic vertebrate non-target model exposed to sublethal concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12...
ORGANISM(S): Danio rerio 
2021-10-11 | E-MTAB-10922 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis steroid inducible RGA expressor transgenic to identify RGA downstream genes
To understand the transcriptional program controlled by RGA, we took advantage of a functional steroid-inducible RGA proteins system in combination with microarray analysis to identify RGA target genes. Experiment Overall Design: We firstly compared the transcriptomes in ga1-3rgargl2RGA-GR infloresc...
ORGANISM(S): Arabidopsis thaliana 
2008-06-18 | E-GEOD-10019 | biostudies-arrayexpress
UnknownBacterial Hydratases Involved in Steroid Side Chain Degradation Have Distinct Substrate Specificities.
Not available
S-EPMC9491828 | biostudies-literature
TranscriptomicsTranscription profiling of mouse model of decidulization and menstruation
A murine model that mimic the decidualization and regression observed in human was used to investigate the molecular mechanisms underlying the dynamic processes in endometrium. Ovariectomized mice were treated sequentially with steroid hormones and then, to induce decidualization, oil was injected i...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6359 | biostudies-arrayexpress
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