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MetabolomicsA cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating heart failure. It is listed as an essential medicine by the World Health Organization. However, how the foxglove plant synthesizes digoxin is mostly unknown, especially the cytochrome P450 sterol side chain...
2025-07-03 | MTBLS7993 | MetaboLights
MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+diet analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4994 | MetaboLights
MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+injury analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4988 | MetaboLights
TranscriptomicsTranscription profiling of yeast mutants to determine gene regulation by sterol and sphingolipid composition
determination of gene regulation by sterol and sphingolipid composition
ORGANISM(S): Saccharomyces cerevisiae 
2009-02-25 | E-TABM-544 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae cultures treated with the saponins tomatidine, tomatine or the sterol biosynthesis inhibitory compound fenpropimorph
Genome-wide expression profiling was used to identify genes that showed altered expression in response to treatment with the saponins tomatidine, tomatine and the sterol biosynthesis inhibitory compound fenpropimorph; Growth inhibition by the compounds was monitored by measuring the OD600nm. Cells w...
ORGANISM(S): Saccharomyces cerevisiae 
2007-09-21 | E-GEOD-4669 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat and mouse granulosa cells infected with adenoviral vectors expressing two FOXO1 mutants reveals FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells
The forkhead box transcription factor FOXO1 is highly expressed in granulosa cells of growing follicles but is down-regulated by FSH in culture or by LH-induced luteinization in vivo. To analyze the function of FOXO1, we infected rat and mouse granulosa cells with adenoviral vectors expressing two F...
ORGANISM(S): Rattus norvegicus 
2009-04-25 | E-GEOD-15727 | biostudies-arrayexpress
ModelsBhattacharya2014 - A mathematical model of the sterol regulatory element binding protein 2 cholesterol biosynthesis pathway
This is a deterministic nonlinear ordinary differential equation mathematical model of the sterol regulatory element binding protein 2 (SREBP-2) cholesterol genetic regulatory pathway in a hepatocyte.
2024-09-02 | BIOMD0000000890 | BioModels
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
GenomicsExamination of hepatic SREBP-2 binding using ChIP-Seq
Sterol regulatory element binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28082 | biostudies-arrayexpress
TranscriptomicsAgricultural sterol biosynthesis inhibitor fungicides
Resistance to agricultural fungicides in the field has created a need for discovering fungicides with new modes of action. DNA microarrays, because they provide information on expression of many genes simultaneously, could help to identify the modes of action. To begin an expression pattern database...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-2412 | biostudies-arrayexpress
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