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GenomicsThe Scc2NIPBL/Scc4MAU2 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions [ChIP-seq]
The Scc2/Scc4 complex binds to broad nucleosome-free regions in the promoters of highly expressed genes. The cohesin loader is recruited to these sites by the RSC chromatin remodeling complex ChIp- Sequencing analysis of the distribution of Scc2 and Scc4 on budding yeast chromosomes.An input sample ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-56993 | biostudies-arrayexpress
GenomicsThe Scc2NIPBL/Scc4MAU2 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions [Mnase-seq]
The Scc2/Scc4 complex binds to broad nucleosome-free regions in the promoters of highly expressed genes. The cohesin loader is recruited to these sites by the RSC chromatin remodeling complex MNase digestion of purified DNA followed by paired-end sequencing was performed in order to investigate geno...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-56992 | biostudies-arrayexpress
TranscriptomicsDefinition of the fibroblast SRF-mediated immediate-early transcriptional response
To control transcription, SRF recruits signal-regulated co-activators, the Ternary Complex Factors (TCFs) and the Myocardin-related Transcription Factors (MRTFs), which compete for a common site on its DNA-binding domain. The TCFs - SAP-1, Elk-1 and Net - are Ets proteins that link SRF activity to R...
ORGANISM(S): Mus musculus 
2014-04-24 | E-GEOD-45888 | biostudies-arrayexpress
TranscriptomicsThe Scc2NIPBL/Scc4MAU2 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions [microarray]
The Scc2/Scc4 complex binds to broad nucleosome-free regions in the promoters of highly expressed genes. The cohesin loader is recruited to these sites by the RSC chromatin remodeling complex Total RNA was isolated from wt, scc2-4 and sth1-3 cells at 25°C and 37°C. dscDNA was obtained using the IV...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-56991 | biostudies-arrayexpress
TranscriptomicsMRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development
Chemokine signaling is important for the seeding of different sites by hematopoietic stem cells during development. Serum Response Factor (SRF) controls multiple genes governing adhesion and migration, mainly by recruiting members of the Myocardin-Related Transcription Factor (MRTF) family of G-acti...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-63820 | biostudies-arrayexpress
Genomicsena-DATASET-CRUK-LRI-04-02-2014-11:46:00:265-3 - samples
Paired end Illumina sequencing of whole exomes of multiple tumour regions.
EGAD00001000734 | EGA
GenomicsGenomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
We applied multi-region exome sequencing to 10 clear cell renal carcinomas to resolve the genetic architecture, intra tumour heterogeneity and evolutionary histories of these tumours.
EGAS00001000667 | EGA
GenomicsTRACERx renal DAC
Data Access Committee EGAC00001001907
EGAC00001001907 | EGA
GenomicsGenome wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts
We have identfied antibodies that support chromatin immunoprecipitation (ChIP) of 11 components of Polycomb repressive complex 1 (PRC1) and shown that multiple variants of PRC1 associate with the same DNA. By performing ChIP-seq with antibodies against CBX6, CBX7, CBX8, RING1 and RING2, in two stra...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-40740 | biostudies-arrayexpress
GenomicsTRACERx: TRAcking non-small cell lung Cancer Evolution through therapy (Rx). Pilot Study. Multi-region sequencing of early-stage NSCLCs.
Deciphering the complexity of non-small cell lung cancer (NSCLC) evolutionary histories may elucidate the basis for its dismal outcome. We performed multi-region sequencing of early-stage NSCLCs. Spatial dissection revealed branched tumor evolution, with driver mutations occurring before and after s...
EGAS00001000809 | EGA
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