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TranscriptomicsSingle-cell RNA and BCR sequencing of naive B cells cultured in IgG class-switching polarising conditions
Naive B cells (CD27-IgD+) were obtained from 3 healthy controls and cultured in vitro under anti-IgM, CD40L and IFN-gamma to polarise class-switching towards IgG isotypes. Single-cell RNA and BCR sequencing libraries were prepared at Day 0 (before addition of stimuli), Day 3 and Day 6 of the cell cu...
ORGANISM(S): Homo sapiens 
2023-07-01 | E-MTAB-13050 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of phenotypically defined human B cell subsets
Separation of B cells has been historically important in discovering their functional relevance, particularly in relation to infection, immune disorders and vaccination. Traditional use of phenotypic markers often poses problems in distinguishing heterogeneous populations such as the Double Negative...
ORGANISM(S): Homo sapiens 
2021-03-19 | E-MTAB-9544 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA and B cell receptor profiling of B cell response to SARS-CoV-2 vaccination
We generated single-cell transcriptomic and BCR sequencing data of B cells from peripheral blood samples taken from a SARS-CoV-2-antigen-naive cohort being vaccinated with the SARS-CoV-2 mRNA-1273 vaccine. Blood samples were collected at the baseline timepoint D-1 (i.e. one day prior to the initial ...
ORGANISM(S): Homo sapiens 
2026-05-08 | E-MTAB-16531 | biostudies-arrayexpress
ProteomicsProteome profiling of mouse germinal center B cells
Productive B cell responses are critical to protect a host from infection. The spleen and lymph nodes are populated by resting follicular B cells, which can enter germinal centers upon antigen encounter. Once in the germinal center, B cells migrate between the dark and light zones, where they underg...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-06 | PXD015524 | Pride
Mouse B cells 
ProteomicsAltered Subgenomic RNA Abundance in SARS-CoV-2 B.1.1.7 Infections
SARS-CoV-2 lineage B.1.1.7 viruses are more transmissible, may lead to greater clinical severity, and result in modest reductions in antibody neutralization. Subgenomic RNA(sgRNA) is produced by discontinuous transcription of the SARS-CoV-2 genome. Applying our tool(periscope) to ARTIC Network Nanop...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2021-11-26 | PXD029954 | Pride
Sars-cov-2 B.1.1.7 Coronavirus 
TranscriptomicsPhevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression
Staphylococcus aureus produces the cyclic dipeptides tyrvalin and phevalin (aureusimine A and B, respectively). A previous study reported that S. aureus mutants not capable of producing these compounds were less virulent in vivo through the deranged regulation of virulence factor genes. These findin...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-32920 | biostudies-arrayexpress
UnknownOn the exoneration of Dr. William H. Stewart: debunking an urban legend.
Not available
S-EPMC3707092 | biostudies-literature
UnknownHepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders.
Not available
S-EPMC4821826 | biostudies-literature
UnknownDesigning Fast-Dissolving Orodispersible Films of Amphotericin B for Oropharyngeal Candidiasis.
Not available
S-EPMC6723921 | biostudies-literature
UnknownB-Cell Activation Gene Signature in Blood and Liver of Hepatitis B e Antigen-Positive Patients With Immune Active Chronic Hepatitis B.
Not available
S-EPMC11646581 | biostudies-literature
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