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TranscriptomicsIdentification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures
Hemogenic endothelium (HE) is the source of HSCs in the developing embryo. In this study we have identified the hemogenic endothelial progenitors and their precursors originating from differentiated H1 cells on OP9 stromal cells. RNA-seq of hemogenic endothelial progenitors and their precursors ori...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-39661 | biostudies-arrayexpress
TranscriptomicsInfectious hematopoietic necrosis virus (IHNV) persistence in Sockeye Salmon: effect on brain transcriptome and response to the viral mimic poly(I:C)
To characterise the transcriptional response in brain of Sockeye Salmon (Oncorhynchus nerka) that were persistently infected with infectious hematopoietic necrosis virus (IHNV) and to determine whether carrying the IHNV affects the ability to respond to other immunological challenges we compared the...
ORGANISM(S): Oncorhynchus nerka 
2015-08-10 | E-GEOD-65241 | biostudies-arrayexpress
ProteomicsSenescent cancer-associated fibroblasts in pancreatic adenocarcinoma impair CD8+ T cell activation and limit responsiveness to immunotherapy in mice
Senescent cells within tumors and their stroma exert complex pro- and anti-tumorigenic functions, yet the potential for targeting such senescent cells for improved therapy remains largely unknown. Here, we uncover the presence of a senescent subset of cancer-associated fibroblasts (CAFs) within panc...
ORGANISM(S): Homo sapiens (Human) 
2024-06-24 | PXD053144 | Pride
: senescence Venetoclax Pancreatic ductal adenocarcinoma (pdac) Senolytics Cancer associated fibroblasts (cafs) Immunotherapy Abt-199 T cells 
UnknownMutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.
Not available
S-EPMC4527483 | biostudies-literature
UnknownCD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment.
Not available
S-EPMC11265648 | biostudies-literature
UnknownSalient experiences are represented by unique transcriptional signatures in the mouse brain.
Not available
S-EPMC5862526 | biostudies-literature
UnknownThe Troublesome Ticks Research Protocol: Developing a Comprehensive, Multidiscipline Research Plan for Investigating Human Tick-Associated Disease in Australia.
Not available
S-EPMC9694322 | biostudies-literature
UnknownThe association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: results from the Burden of Obstructive Lung Disease (BOLD) study.
Not available
S-EPMC10207810 | biostudies-literature
UnknownComprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.
Not available
S-EPMC7058534 | biostudies-literature
UnknownTumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes.
Not available
S-EPMC10982990 | biostudies-literature
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