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UnknownPhase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors.
Not available
S-EPMC4104289 | biostudies-literature
TranscriptomicsRNA-seq of mouse embryonic stem cells with knockout of Nhlrc2 gene or addition of FINCA disease causing NHLRC2 p.Asp148Tyr variant
Fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA) (OMIM 618278) is a rare infantile-onset disease caused by variants in NHL repeat containing 2 (NHLRC2) gene. NHLRC2 is essential for mouse gastrulation (Hiltunen et al., 2022). Here, RNA sequencing was performed on four wild type (WT), f...
ORGANISM(S): Mus musculus 
2025-05-22 | E-MTAB-14174 | biostudies-arrayexpress
UnknownPhase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors.
Not available
S-EPMC4486055 | biostudies-literature
TranscriptomicsEffect of LAP2alpha knockout in primary mouse myoblasts
To identify genes and molecular pathways directly or indirectly affected by the loss of LAP2? in skeletal muscle, gene expression profiles of primary Lap2?+/+ (n=3) and Lap2?-/- (n=3) neonatal

myoblasts were compared.
ORGANISM(S): Mus musculus 
2010-05-26 | E-MEXP-2200 | biostudies-arrayexpress
UnknownGenomic profiling of mycosis fungoides identifies patients at high risk of disease progression.
Not available
S-EPMC11222946 | biostudies-literature
TranscriptomicsLong noncoding RNAs are spatially correlated with transcription factors and regulate lung development
To identify potential biological functions for three lncRNAs (NANCI, LL12, and LL34) we used shRNAs to knockdown expression of lncRNAs in MLE12 cells, a cell resembling type two lung epithelial cells. This data set contains the microarrays looking at gene expression. We used biological triplicate fo...
ORGANISM(S): Mus musculus 
2014-07-22 | E-GEOD-52389 | biostudies-arrayexpress
TranscriptomicsMicroarray evidence for off target effects and the optimisation of targeted RNAi mediated gene silencing in the cattle tick Rhipicephalus (Boophilus) microplus
The NimbleGen cattle tick custom microarray based on the BmiGI.V2 database of R. microplus ESTs was used to screen the resulting mRNA harvested from ticks treated with the tick Ubiquitin-63E 600bp dsRNA in comparison to controls. A total of 144 ESTs including TC6372 (Ubiquitin-63E) were down-regulat...
ORGANISM(S): Rhipicephalus microplus 
2011-07-30 | E-GEOD-27453 | biostudies-arrayexpress
TranscriptomicsPemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma
We devised a high-throughput, cell-based assay to identify novel therapeutic compounds to treat Group3 medulloblastoma (G3 MB). Mouse G3 MBs, grown as neurospheres, were screened against a library of approximately 7,000 compounds including FDA-approved drugs. We identified two FDA-approved drugs, ...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-46406 | biostudies-arrayexpress
MetabolomicsInsights into Metabolic Changes Caused by the Trichoderma virens-Maize Root Interaction
The interactions of crops with root-colonizing endophytic microorganisms are highly relevant to agriculture, because endophytes can modify plant resistance to pests and increase crop yields. We investigated the interactions between the host plant Zea mays and the endophytic fungus Trichode...
2021-07-08 | MTBLS1964 | MetaboLights
UnknownEfficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer: Final Analysis of the CALOR Trial.
Not available
S-EPMC5891132 | biostudies-literature
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